A Randomized, Placebo-Controlled Trial Of Arginine Therapy For The Treatment Of Children With Sickle Cell Disease Hospitalized With Vaso-Occlusive Pain Episodes

• Authors: Claudia R. Morris, Emory University; Frans A. Kuypers, Children’s Hospital Oakland Research Institute; Lisa Lavrisha, Children’s Hospital and Research Center Oakland; Michael Ansari, Children’s Hospital and Research Center Oakland; Nancy Sweeters, Children’s Hospital and Research Center Oakland; Melinee Stewart, Children’s Hospital and Research Center Oakland; Ginny Gildengorin, Children’s Hospital Oakland Research Institute; Lynne Neumayr, Children’s Hospital and Research Center Oakland; Elliott P. Vichinsky, Children’s Hospital and Research Center Oakland
• Journal Title: Haematologica
• Volume: Volume 98, Number 9
• Publisher: Ferrata Storti Foundation | 2013-09, Pages 1375-1382
• Type of Work: Article | Final Publisher PDF
• Publisher DOI: http://doi.org/10.3324/haematol.2013.086637
• Subjects: Health Sciences, Medicine and Surgery; Health Sciences, Human Development

Abstract

Painful episodes of vaso-occlusion are the leading cause of hospitalizations and emergency department visits in sickle cell disease, and are associated with increased mortality. Low nitric oxide bioavailability contributes to vasculopathy in sickle cell disease. Since arginine is the obligate substrate for nitric oxide production, and an acute deficiency is associated with pain, we hypothesized that arginine may be a beneficial treatment for pain related to sickle cell disease. Thirty-eight children with sickle cell disease hospitalized for 56 episodes of pain were randomized into this double-blinded placebo-controlled trial. Patients received L-arginine (100 mg/kg tid) or placebo for 5 days or until discharge. A significant reduction in total parenteral opioid use by 54% (1.9±2.0 mg/kg versus 4.1±4.1 mg/kg, P=0.02) and lower pain scores at discharge (1.9±2.4 versus 3.9±2.9, P=0.01) were observed in the treatment arm compared to the placebo one. There was no significant difference in hospital length of stay (4.1±01.8 versus 4.8±2.5 days, P=0.34), although a trend favored the arginine arm, and total opioid use was strongly correlated with the duration of the admission (r=0.86, P<0.0001). No drug-related adverse events were observed. Arginine therapy represents a novel intervention for painful vaso-occlusive episodes. A reduction of narcotic use by >50% is remarkable. Arginine is a safe and inexpensive intervention with narcotic-sparing effects that may be a beneficial adjunct to standard therapy for sickle cell-related pain in children. A large multi-center trial is warranted in order to confirm these observations.