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Author Notes:

Correspondence to Keivan Zandi. Email: keivan@um.edu.my

Conceived and designed the experiments: K.Z., S.A.B. Performed the experiments: E.M., B.T.T., P.H., S.S.S., R.L. Analyzed the data: K.Z., S.S.B., A.Y., E.M., Z.C. Contributed essential reagents: A.Y.

Wrote the manuscript: E.M., K.Z., A.Y., S.A.B. All authors reviewed the manuscript.

The authors declare no competing financial interests.

Subjects:

Research Funding:

The authors would like to thank the Ministry of Higher Education (MOHE), Malaysia, for High Impact Research (HIR) MOHE Grant (E000087-20001) and Long-Range Grant Scheme (LRGS) LR001/2011F.

They also would like to thank the University of Malaya for University Malaya Research Grant (UMRG) (RG383-11HTM).

Keywords:

  • Science & Technology
  • Multidisciplinary Sciences
  • Science & Technology - Other Topics
  • IN-VITRO
  • FLAVONOIDS
  • TYPE-2
  • DISCOVERY
  • REPLICATION
  • CELLS

Baicalin, a metabolite of baicalein with antiviral activity against dengue virus

Tools:

Journal Title:

Scientific Reports

Volume:

Volume 4, Number 1

Publisher:

, Pages 5452-5452

Type of Work:

Article | Final Publisher PDF

Abstract:

Baicalin, a flavonoid derived from Scutellaria baicalensis, is the main metabolite of baicalein released following administration in different animal models and human. We previously reported the antiviral activity of baicalein against dengue virus (DENV). Here, we examined the anti-DENV properties of baicalin in vitro, and described the inhibitory potentials of baicalin at different steps of DENV-2 (NGC strain) replication. Our in vitro antiviral experiments showed that baicalin inhibited virus replication at IC 50 = 13.5 ± 0.08 1/4g/ml with SI = 21.5 following virus internalization by Vero cells. Baicalin exhibited virucidal activity against DENV-2 extracellular particles at IC 50 = 8.74 ± 0.08â 1/4g/ml and showed anti-adsorption effect with IC 50 = 18.07 ± 0.2â 1/4g/ml. Our findings showed that baicalin as the main metabolite of baicalein exerting in vitro anti-DENV activity. Further investigations on baicalein and baicalin to deduce its antiviral therapeutic effects are warranted.

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© 2014, Macmillan Publishers Limited. All rights reserved

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (http://creativecommons.org/licenses/by-nc-sa/4.0/).

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