A 65-year-old male with end-stage liver disease secondary to alcoholic cirrhosis was admitted to Emory University Hospital after experiencing progressive lethargy and displaying combative behavior. The patient was diagnosed with hepatic encephalopathy as well as hepatorenal syndrome. Inpatient work-up indicated that the patient was an appropriate liver transplant candidate, but he developed refractory hypotension within days of being placed on the transplant list. Although the patient was afebrile, the clinical team collected peripheral blood cultures (one set) to rule out bacteremia as a cause of the patient's hypotension.