About this item:
249 Views | 327 Downloads
Author Notes:
E-mail: drew@mail.med.upenn.edu
Conceived and designed the experiments: JKS ESD LL ARK DW. Performed the experiments: YZ HN ML JKS ESD LL. Analyzed the data: ARK DW.
Contributed reagents/materials/analysis tools: JKS ESD LL ARK DW.
Wrote the paper: YZ ML DW.
The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Subjects:
Research Funding:
This research was funded by a grant from the National Space Biomedical Research Institute (NSBRI) through NASA NCC 9-58, http://www.nsbri.org/
Keywords:
- Science & Technology
- Multidisciplinary Sciences
- Science & Technology - Other Topics
- INTERNATIONAL-SPACE-STATION
- CYTOKINE PRODUCTION
- SOLUBLE CD14
- BINDING PROTEIN
- HIV-INFECTION
- PLASMA-LEVELS
- FLIGHT
- SPACEFLIGHT
- RESPONSES
- MODEL
Effect of Solar Particle Event Radiation and Hindlimb Suspension on Gastrointestinal Tract Bacterial Translocation and Immune Activation
Abstract:
The environmental conditions that could lead to an increased risk for the development of an infection during prolonged space flight include: microgravity, stress, radiation, disturbance of circadian rhythms, and altered nutritional intake. A large body of literature exists on the impairment of the immune system by space flight. With the advent of missions outside the Earth's magnetic field, the increased risk of adverse effects due to exposure to radiation from a solar particle event (SPE) needs to be considered. Using models of reduced gravity and SPE radiation, we identify that either 2 Gy of radiation or hindlimb suspension alone leads to activation of the innate immune system and the two together are synergistic. The mechanism for the transient systemic immune activation is a reduced ability of the GI tract to contain bacterial products. The identification of mechanisms responsible for immune dysfunction during extended space missions will allow the development of specific countermeasures.
Copyright information:
© 2012 Zhou et al
This is an Open Access work distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/).
