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Author Notes:

Address correspondence to Philip N. Rather, prather@emory.edu.

We are grateful to Julian Davies for the suggestion to use myomycin in this study and for providing this antibiotic.

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Research Funding:

This work was supported, in part, by a grant from the Atlanta Research and Education Foundation to P.N.R. and by R01AI072219-01A1 from the National Institutes of Health.

P.N.R. is supported by a Research Career Scientist award from the Department of Veterans Affairs.

Streptomycin Inhibits Quorum Sensing in Acinetobacter baumannii

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Journal Title:

Antimicrobial Agents and Chemotherapy

Volume:

Volume 57, Number 4

Publisher:

, Pages 1926-1929

Type of Work:

Article | Final Publisher PDF

Abstract:

Streptomycin at subinhibitory concentrations was found to inhibit quorum sensing in Acinetobacter baumannii. Conditioned medium prepared by growth of A. baumannii in the presence of subinhibitory concentrations of streptomycin exhibited reduced activation of two quorum-sensing-regulated genes, abaI, encoding an autoinducer synthase, and A1S_0112. The reduced expression of AbaI resulted in greatly decreased levels of 3-OH-C12-HSL as confirmed by direct analysis using thin-layer chromatography. The effect on acyl-homoserine lactone (AHL) signal production was specific to streptomycin, as gentamicin and myomycin had no significant effect at subinhibitory levels.

Copyright information:

© 2013, American Society for Microbiology. All Rights Reserved.

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