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Author Notes:
Address correspondence to: Keqiang Ye (kye@emory.edu).
These authors contributed equally to this work.
Subject:
Research Funding:
This work is supported by a grant from NIH (RO1, CA127119; NS-045627) to K. Ye.
Akt-phosphorylated PIKE-A inhibits UNC5B-induced apoptosis in cancer cell lines in a p53-dependent manner
Abstract:
UNC5B induces apoptosis in the absence of its cognate ligand netrins and acts as a tumor suppressor. UNC5B is a direct transcriptional target of p53 upon UV stimulation. Here we show that Akt phosphorylates PIKE-A and regulates its association with UNC5B and inhibits UNC5B-provoked apoptosis in a p53-dependent manner.
Copyright information:
© 2011 He et al.
This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License (http://creativecommons.org/licenses/by-nc-sa/3.0/).
