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Author Notes:

Corresponding author. Tel.: +1 708 327 2477; ekovacs@lumc.edu (E.J. Kovacs)

The authors would also like to thank Letta Kochalis for technical and logistical support.

Subjects:

Research Funding:

The authors and participants would like to thank the NIAAA (AA016751), the Loyola University Chicago Burn and Shock Trauma Institute, and the Alcohol Research Program for financial support of the meeting. Support was also provided by NIH R13 AA017084, R01 AA012034 (EJK), R13 AA 020768 (EJK), F31 AA019913 (AZ) and T32 AA013527 (EJK).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Substance Abuse
  • Pharmacology & Pharmacy
  • Toxicology
  • Alcohol
  • Epigenetics
  • Histone
  • Immune response
  • Inflammation
  • HISTONE H3 MODIFICATIONS
  • GENE-EXPRESSION
  • DOWN-REGULATION
  • UP-REGULATION
  • ETHANOL
  • MECHANISM
  • EXPOSURE
  • SYSTEM
  • INJURY
  • CELLS

Alcohol and epigenetic changes: Summary of the 2011 Alcohol and Immunology Research Interest Group (AIRIG) meeting

Tools:

Journal Title:

Alcohol

Volume:

Volume 46, Number 8

Publisher:

, Pages 783-787

Type of Work:

Article | Post-print: After Peer Review

Abstract:

On November 18, 2011, the 16th annual Alcohol and Immunology Research Interest Group (AIRIG) meeting was held at Loyola University Medical Center in Maywood, Illinois. The focus of this year's meeting was alcohol's effect on epigenetic changes and possible outcomes induced by these changes. Two sessions, which consisted of talks from invited speakers as well as presentations of selected abstracts, were held in addition to a poster session. Participants presented information on alcohol-induced alterations in histone modifications and gene expression along with immunologic responses to alcohol. Speakers shared new research specifically on histone deacetylase enzyme expression and modifications due to alcohol and the downstream effect of these modifications may have on gene expression and tissue damage. Additional studies suggested that alcohol exacerbates inflammation when combined with other insults such as infection, trauma, inhalation injury, and disease.

Copyright information:

© 2012 Elsevier Inc.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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