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Author Notes:

Corresponding author:hjiang@bme.ufl.edu

Subjects:

Research Funding:

This research was supported in part by the J. Crayton Pruitt Endowment and by a grant from the NIH (R01 CA133722).

Keywords:

  • Science & Technology
  • Physical Sciences
  • Optics
  • DIFFUSE OPTICAL TOMOGRAPHY
  • IN-VIVO
  • BREAST-CANCER
  • TUMOR MARGINS
  • MEMS MIRROR

Microelectromechanical systems scanning-mirror-based handheld probe for fluorescence molecular tomography

Tools:

Journal Title:

Applied Optics

Volume:

Volume 51, Number 20

Publisher:

, Pages 4678-4683

Type of Work:

Article | Post-print: After Peer Review

Abstract:

A novel handheld probe based on a microelectromechanical systems (MEMS) scanning mirror for three-dimensional (3D) fluorescence molecular tomography (FMT) is described. The miniaturized probe consists of a MEMS mirror for delivering an excitation light beam to multiple preselected points at the tissue surface and an optical fiber array for collecting the fluorescent emission light from the tissue. Several phantom experiments based on indocyanine green, an FDA approved near-infrared (NIR) fluorescent dye, were conducted to assess the imaging ability of this device. Tumor-bearing mice with systematically injected tumor-targeted NIR fluorescent probes were scanned to further demonstrate the ability of this MEMS-based FMT for imaging small animals.

Copyright information:

© 2012 Optical Society of America.

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