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Author Notes:

Milan Toma, Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Technology Enterprise Park, Suite 200, 387 Technology Circle, Atlanta, GA 30313-2412, U.S.A., E-mail address: toma@gatech.edu.

No benefits in any form have been or will be received from a commercial party related directly or indirectly to the subject of this manuscript.

Subjects:

Research Funding:

This study was supported by a grant from the National Heart Lung and Blood Institute (R01-HL092926).

Keywords:

  • Science & Technology
  • Technology
  • Life Sciences & Biomedicine
  • Physical Sciences
  • Engineering, Biomedical
  • Mathematical & Computational Biology
  • Mathematics, Interdisciplinary Applications
  • Engineering
  • Mathematics
  • fluid-structure interaction
  • mitral valve
  • forces
  • comprehensive computational model
  • papillary muscle
  • chordal structure
  • chordae tendineae
  • FINITE-ELEMENT MODEL
  • PAPILLARY-MUSCLE
  • REPLACEMENT
  • REGURGITATION
  • DILATATION
  • TENDINEAE
  • DYNAMICS
  • STRESSES
  • SUTURE

Fluid-Structure Interaction and Structural Analyses using a Comprehensive Mitral Valve Model with 3D Chordal Structure

Tools:

Journal Title:

International Journal for Numerical Methods in Biomedical Engineering

Volume:

Volume 33, Number 4

Publisher:

, Pages e2815-e2815

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Over the years, three-dimensional models of the mitral valve have generally been organized around a simplified anatomy. Leaflets have been typically modeled as membranes, tethered to discrete chordae typically modeled as one-dimensional, non-linear cables. Yet, recent, high-resolution medical images have revealed that there is no clear boundary between the chordae and the leaflets. In fact, the mitral valve has been revealed to be more of a webbed structure whose architecture is continuous with the chordae and their extensions into the leaflets. Such detailed images can serve as the basis of anatomically accurate, subject-specific models, wherein the entire valve is modeled with solid elements that more faithfully represent the chordae, the leaflets, and the transition between the two. These models have the potential to enhance our understanding of mitral valve mechanics and to re-examine the role of the mitral valve chordae, which heretofore have been considered to be ‘invisible’ to the fluid and to be of secondary importance to the leaflets. However, these new models also require a rethinking of modeling assumptions. In this study, we examine the conventional practice of loading the leaflets only and not the chordae in order to study the structural response of the mitral valve apparatus. Specifically, we demonstrate that fully resolved 3D models of the mitral valve require a fluid–structure interaction analysis to correctly load the valve even in the case of quasi-static mechanics. While a fluid–structure interaction mode is still more computationally expensive than a structural-only model, we also show that advances in GPU computing have made such models tractable.

Copyright information:

© 2016 John Wiley & Sons, Ltd.

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