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Author Notes:

Erik Reinertsen Emory University School of Medicine, 100 Woodruff Circle, Atlanta, GA 30322, USA. Email: ereiner@emory.edu

The author(s) received no financial support for the research, authorship, and/or publication of this article.

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.



  • crystalloid
  • meningioma
  • tyrosine

Meningioma With Tyrosine-Rich Crystalloids: A Case Report and Review of the Literature


Journal Title:

International Journal of Surgical Pathology


Volume 26, Number 2


, Pages 157-160

Type of Work:

Article | Post-print: After Peer Review


We report a case of fibrous meningioma with tyrosine-rich crystalloid in the frontal lobe of a middle-aged woman. The patient presented with a history of several years of worsening headaches and blurry vision, which progressed to include syncopal episodes and right-sided weakness. Imaging demonstrated a dural-based extra-axial mass arising from the right orbital roof and extending superiorly along the right frontal convexity causing right-to-left midline shift. The patient underwent a craniotomy and operative resection. Tumor architecture and cytology was similar to that of a Schwannian neoplasm, with spindled cells arranged in a fascicular architecture and displaying focal nuclear palisading. Immunohistochemical stains confirmed a diagnosis of fibrous meningioma. Light microscopy demonstrated extracellular deposits of eosinophilic crystalline material parallel to the spindled tumor cells, reminiscent of “tyrosine-rich” crystals described in salivary gland neoplasms. This is the third meningioma featuring tyrosine-rich crystalloid reported in the literature; we also summarize the previous 2 reports.

Copyright information:

© 2017, © The Author(s) 2017.

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