About this item:

134 Views | 125 Downloads

Author Notes:

Shannon L. Gourley, Email: shannon.l.gourley@emory.edu.

E.P. and S.G. designed the experiments and prepared the manuscript. E.P. and D.L. conducted the experiments and statistical analyses.

D.L. assisted with manuscript editing.

We thank A. Allen, Mr. Michael Bower and Dr. Alonzo Whyte for their contributions.

Thank you also to Dr. Kerry Ressler for the use of the TrkB.t1-expressing lentivirus.

The authors declare no competing interests.

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.


Research Funding:

This work was supported by NIH MH101477.

The Yerkes National Primate Research Center is supported by the Office of Research Infrastructure Programs/OD P51 OD011132.

The Emory Viral Vector Core is supported by an NINDS Core Facilities grant, P30 NS055077.


  • Science & Technology
  • Multidisciplinary Sciences
  • Science & Technology - Other Topics
  • BDNF

Bidirectional coordination of actions and habits by TrkB in mice


Journal Title:

Scientific Reports


Volume 8, Number 1


, Pages 4495-4495

Type of Work:

Article | Final Publisher PDF


Specific corticostriatal structures and circuits are important for flexibly shifting between goal-oriented versus habitual behaviors. For example, the orbitofrontal cortex and dorsomedial striatum are critical for goal-directed action, while the dorsolateral striatum supports habits. To determine the role of neurotrophin signaling, we overexpressed a truncated, inactive form of tropomyosin receptor kinase B [also called tyrosine receptor kinase B (TrkB)], the high-affinity receptor for Brain-derived Neurotrophic Factor, in the orbitofrontal cortex, dorsomedial striatum and dorsolateral striatum. Overexpression of truncated TrkB interfered with phosphorylation of full-length TrkB and ERK42/44, as expected. In the orbitofrontal cortex and dorsomedial striatum, truncated trkB overexpression also occluded the ability of mice to select actions based on the likelihood that they would be reinforced. Meanwhile, in the dorsolateral striatum, truncated trkB blocked the development of habits. Thus, corticostriatal TrkB-mediated plasticity appears necessary for balancing actions and habits.

Copyright information:

© The Author(s) 2018

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
Export to EndNote