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Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322, USA Manish C. Pathak & Eric A. Ortlund.
J.M.L. designed and executed the experiments, interpreted data and cowrote the manuscript.
Y.K.L. and J.L.M. helped with experiments.
S.A.B. and P.R.G. performed the fluorescence binding experiments, and M.C.P. and E.A.O. performed the mass spectrometry experiment. D.D.M. supervised the design and interpretation of the experiments and cowrote the manuscript.
The authors declare no competing financial interests.
We thank Steven A. Kliewer and David J. Mangelsdorf (UT Southwestern Medical Center) for the generous gift of Lrh-1f/f mice, Austin J. Cooney for the Oct4 promoter constructs, Charity Mills and Dana Kuruvilla for experimental assistance, the BCM Diabetes Endocrine Research Center (supported by NIH DK-079638) and the services of the Mouse Metabolism Core for hyperinsulinemic clamp studies, and the current and previous members of the Moore laboratory for helpful discussions and technical support.
Supported by NIH R01 DK068804, the Alkek Foundation and the Robert R. P. Doherty Jr. Welch Chair in Science to D.D.M., and NIH R01 CA134873 to P.R.G.
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