325 Views | 339 Downloads
Correspondence should be addressed to G.G. (greg.gibson@biology.gatech.edu).
U.M.M. and G.G. conceived the theoretical framework for the TRSs.
L.A.D., J.S.H. and S.K. participated in the conception and design of the RISK study.
K.M., J.P., T.D.W., A.G., J.D.N., W.V.C., J.R.R., D.R.M., R.K., M.B.H., S.S.B., M.C.S., R.N.B., J.F.M., M.C.D., B.J.A., M.-O. K. and J.C. recruited subjects, collected the data, and worked on its curation and analysis.
U.M.M. performed the TRS analyses.
U.M.M. and G.G. interpreted the results and drafted the manuscript, while L.A.D., J.S.H. and S.K. assisted with results interpretation and writing.
We are grateful to B. Zeng, D. Arafat, H. Somineni, S. Venkateswaran, and colleagues from the Gibson and Kugathasan laboratories for their support and helpful comments.
We also would like to thank I. Mendizabal, J. Lachance and K. Jordan for comments on the manuscript.
The authors declare no competing financial interests.
This research was supported by Project 3 (G.G., PI) of the NIH program project “Statistical and Quantitative Genetics” grant P01-GM0996568 (B. Weir, University of Washington, Director) as well as research grants from the Crohn's and Colitis Foundation of America (CCFA), New York, to the individual study institutions participating in the RISK study.
© 2017 Nature America, Inc., part of Springer Nature. All rights reserved.