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Author Notes:

Corresponding authors: Simon R. Blakely and Cora E. Macbeth Department of Chemistry, Emory University, USA E-mail: sblakey@emory.edu, cmacbet@emory.edu

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Research Funding:

This research was supported by the National Science Foundation under the Center for Chemical Innovation in Selective C–H Functionalization (CHE-1205646).

Cobalt catalyzed sp3 C–H amination utilizing aryl azides

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Journal Title:

Chemical Science

Volume:

Volume 6, Number 11

Publisher:

, Pages 6672-6675

Type of Work:

Article | Final Publisher PDF

Abstract:

A dinuclear Co(ii) complex supported by a modular, tunable redox-active ligand system is capable of selective C-H amination to form indolines from aryl azides in good yields at low (1 mol%) catalyst loading. The reaction is tolerant of medicinally relevant heterocycles, such as pyridine and indole, and can be used to form 5-, 6-, and 7-membered rings. The synthetic versatility obtained using low loadings of an earth abundant transition metal complex represents a significant advance in catalytic C-H amination technology.

Copyright information:

© 2015 The Royal Society of Chemistry.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/).

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