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Author Notes:

R. E. Guldberg at robert.guldberg@me.gatech.edu

Subjects:

Research Funding:

Financial support from NIH #R01AR069297 and NIH #R01HL131856 is greatly acknowledged.

Keywords:

  • Science & Technology
  • Technology
  • Materials Science, Multidisciplinary
  • Materials Science
  • GROWTH-FACTOR-BETA
  • ENDOTHELIAL-CELLS
  • EXTRACELLULAR-MATRIX
  • IN-VITRO
  • PROTEOGLYCANS
  • EXPRESSION
  • FIBRILLOGENESIS
  • ULTRASTRUCTURE
  • MICROVESSELS
  • FIBROBLASTS

Decorin-containing collagen hydrogels as dimensionally stable scaffolds to study the effects of compressive mechanical loading on angiogenesis

Tools:

Journal Title:

MRS Communications

Volume:

Volume 7, Number 3

Publisher:

, Pages 466-471

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Angiogenesis is a critical component during wound healing, and the process is sensitive to mechanical stimuli. Current in vitro culture environments used to investigate three-dimensional microvascular growth often lack dimensional stability and the ability to withstand compression. We investigated the ability of decorin (DCN), a proteoglycan known to modulate collagen fibrillogenesis, incorporated into a collagen hydrogel to increase construct dimensional stability while maintaining vascular growth. DCN did not affect microvascular growth parameters, while increasing the compressive modulus of collagen gels and significantly reducing the contraction of 3% collagen gels after 16 days in culture.

Copyright information:

© 2017 Materials Research Society.

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