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Author Notes:

Correspondence: Adolfo Ramirez-Zamora adolfo.ramirez-zamora@neurology.ufl.edu

AR-Z, JG, AG, PB, JS, KF, LA, PhS, HB-S, WH, CM, WG, DK, WMG, HW, MJ, JV, DG, DR, DS, TB, RH, SD, LH, NS, PaS, GW, VT, HM, JJ-S, PN, SS, RG, SFL, LL, WD, and MO fulfilled the authorship criteria by substantial contributions to the conception of the work, providing data for the work, revisiting it critically for important intellectual content, approving the final version, and agreeing to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

SFL would like to thank Erika Woodrum (Louis Stokes Cleveland Veterans Affairs Medical Center) and Nicholas Maling, Ph.D. (Case Western Reserve University) for assistance generating Figure 7.

SS would like to acknowledge the Sackler and Gerstner Foundation for their support.

JJ-S would like to thank the Michael J Fox Foundation for Parkinson's Research for providing a project planning grant for the development of RAD-PD design and infrastructure.

Furthermore, RAD-PD is an approved study through the Parkinson Study Group and includes participation of Patient Advocates from the Parkinson Disease Foundation.

JJ-S also would like to acknowledge the following collaborators and co-investigators: Nuri F. Ince, Ph.D.; Ilknur Telkes, Ph.D.; Ashwin Viswanathan, MD.


Research Funding:

JG is supported in part by funding from the European Union's Horizon 2020 Research and Innovation Program under grant agreement 720270: HBP SGA1, by the AEHS Foundation, and by federal funds UL1TR001409 from the National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, through the Clinical and Translational Science Awards Program (CTSA), a trademark of the Department of Health and Human Services, part of the Roadmap Initiative, “Re-Engineering the Clinical Research Enterprise.”

DS, TB, RH, and SD: this work was supported by DARPA RAM program (N66001-14-2-4032, N66001-14-C-4016).

LL would like to acknowledge grant support NSFC No. 81527901, No. 61601258, and 2016YFC0105502 2016YFC0105900.

HW is supported by NIH grant UH3NS100553.


  • Science & Technology
  • Life Sciences & Biomedicine
  • Neurosciences
  • Neurosciences & Neurology
  • deep brain stimulation
  • neuromodulation
  • epilepsy
  • Parkinson's disease
  • tremor
  • obsessive compulsive disorder
  • tourette syndrome
  • memory

Evolving Applications, Technological Challenges and Future Opportunities in Neuromodulation: Proceedings of the Fifth Annual Deep Brain Stimulation Think Tank

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Journal Title:

Frontiers in Neuroscience


Volume 11, Number JAN


, Pages 734-734

Type of Work:

Article | Final Publisher PDF


The annual Deep Brain Stimulation (DBS) Think Tank provides a focal opportunity for a multidisciplinary ensemble of experts in the field of neuromodulation to discuss advancements and forthcoming opportunities and challenges in the field. The proceedings of the fifth Think Tank summarize progress in neuromodulation neurotechnology and techniques for the treatment of a range of neuropsychiatric conditions including Parkinson's disease, dystonia, essential tremor, Tourette syndrome, obsessive compulsive disorder, epilepsy and cognitive, and motor disorders. Each section of this overview of the meeting provides insight to the critical elements of discussion, current challenges, and identified future directions of scientific and technological development and application. The report addresses key issues in developing, and emphasizes major innovations that have occurred during the past year. Specifically, this year's meeting focused on technical developments in DBS, design considerations for DBS electrodes, improved sensors, neuronal signal processing, advancements in development and uses of responsive DBS (closed-loop systems), updates on National Institutes of Health and DARPA DBS programs of the BRAIN initiative, and neuroethical and policy issues arising in and from DBS research and applications in practice.

Copyright information:

© 2018 Ramirez-Zamora, Giordano, Gunduz, Brown, Sanchez, Foote, Almeida, Starr, Bronte-Stewart, Hu, McIntyre, Goodman, Kumsa, Grill, Walker, Johnson, Vitek, Greene, Rizzuto, Song, Berger, Hampson, Deadwyler, Hochberg, Schiff, Stypulkowski, Worrell, Tiruvadi, Mayberg, Jimenez-Shahed, Nanda, Sheth, Gross, Lempka, Li, Deeb and Okun.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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