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Author Notes:

Correspondence: burton@scripps.edu

Subject:

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Microbiology
  • Parasitology
  • Virology
  • IMMUNODEFICIENCY-VIRUS TYPE-1
  • T FOLLICULAR HELPER
  • AUTOLOGOUS NEUTRALIZING ANTIBODY
  • RESPIRATORY SYNCYTIAL VIRUS
  • HUMAN MONOCLONAL-ANTIBODIES
  • VESICULAR STOMATITIS-VIRUS
  • SITE-SPECIFIC ANALYSIS
  • CD4 BINDING-SITE
  • ENVELOPE GLYCOPROTEINS
  • B-CELLS

A Blueprint for HIV Vaccine Discovery

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Journal Title:

Cell Host and Microbe

Volume:

Volume 12, Number 4

Publisher:

, Pages 396-407

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Despite numerous attempts over many years to develop an HIV vaccine based on classical strategies, none has convincingly succeeded to date. A number of approaches are being pursued in the field, including building upon possible efficacy indicated by the recent RV144 clinical trial, which combined two HIV vaccines. Here, we argue for an approach based, in part, on understanding the HIV envelope spike and its interaction with broadly neutralizing antibodies (bnAbs) at the molecular level and using this understanding to design immunogens as possible vaccines. BnAbs can protect against virus challenge in animal models, and many such antibodies have been isolated recently. We further propose that studies focused on how best to provide T cell help to B cells that produce bnAbs are crucial for optimal immunization strategies. The synthesis of rational immunogen design and immunization strategies, together with iterative improvements, offers great promise for advancing toward an HIV vaccine.

Copyright information:

© 2012 Elsevier Inc.

This is an Open Access work distributed under the terms of the Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported License (http://creativecommons.org/licenses/by-nc-nd/3.0/).

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