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Author Notes:

Corresponding author: Dalin Tang, dtang@wpi.edu

Consultations and guidance from Professor Roger Kamm at MIT are happily acknowledged.


Research Funding:

This research was supported in part by NIH Grant R01 EB004759 and a Jiangsu Province Science and Technology Agency grant BE2016785.


  • Science & Technology
  • Life Sciences & Biomedicine
  • Technology
  • Biophysics
  • Engineering, Biomedical
  • Engineering
  • Vulnerable plaque
  • Artery material properties
  • Patient-specific model
  • FSI
  • IVUS
  • MRI
  • RISK

Quantify patient-specific coronary material property and its impact on stress/strain calculations using in vivo IVUS data and 3D FSI models: a pilot study

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Journal Title:

Biomechanics and Modeling in Mechanobiology


Volume 16, Number 1


, Pages 333-344

Type of Work:

Article | Post-print: After Peer Review


Computational models have been used to calculate plaque stress and strain for plaque progression and rupture investigations. An intravascular ultrasound (IVUS)-based modeling approach is proposed to quantify in vivo vessel material properties for more accurate stress/strain calculations. In vivo Cine IVUS and VH-IVUS coronary plaque data were acquired from one patient with informed consent obtained. Cine IVUS data and 3D thin-slice models with axial stretch were used to determine patient-specific vessel material properties. Twenty full 3D fluid–structure interaction models with ex vivo and in vivo material properties and various axial and circumferential shrink combinations were constructed to investigate the material stiffness impact on stress/strain calculations. The approximate circumferential Young’s modulus over stretch ratio interval [1.0, 1.1] for an ex vivo human plaque sample and two slices (S6 and S18) from our IVUS data were 1631, 641, and 346 kPa, respectively. Average lumen stress/strain values from models using ex vivo, S6 and S18 materials with 5 % axial shrink and proper circumferential shrink were 72.76, 81.37, 101.84 kPa and 0.0668, 0.1046, and 0.1489, respectively. The average cap strain values from S18 material models were 150–180 % higher than those from the ex vivo material models. The corresponding percentages for the average cap stress values were 50–75 %. Dropping axial and circumferential shrink consideration led to stress and strain over-estimations. In vivo vessel material properties may be considerably softer than those from ex vivo data. Material stiffness variations may cause 50–75 % stress and 150–180 % strain variations.

Copyright information:

© 2016, Springer-Verlag Berlin Heidelberg.

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