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Author Notes:

Co-correspondence authors: gming@mail.med.upenn.edu (G.M), tang@bio.fsu.edu (H.T), zhxu@genetics.ac.cn (Z.X), peng.jin@emory.edu (P.J).

Y.O.: conception and study design, performing experiments, data analysis, data assembly, and interpretation of data, and writing manuscript; F.Z., Y.W., E.M.L., Q.-F.W., I.Y.C., H.L., F.M., R.L., L.H., T.X., C.L., Z.W. and C.F.Q.: performing experiments and/or data analysis; H.W., H.T., Z.X., P.J., H.S., G.M., and G.L.: study design and data analysis; H.T., Z.X., P.J., H.S., G.M., and G.L.: conception and study design, data analysis and interpretation, and writing manuscript.

We thank Dr. Kimberly M. Christian for comments.

We acknowledge the services of Hao Zhang at Flow Cytometry Core Facility (JHSPH), Weining Tang at Omega Bioservices (Omega Bio-tek, Inc.), and Mike Zwick and Ben Isett at the Emory Integrated Genomics Core (EIGC).

The authors declare no competing financial interests.

Subjects:

Research Funding:

This work was supported by grants from the Robertson Investigator Award from New York Stem Cell Foundation (G.L.), Maryland Stem Cell Research Funding (MSCRF; G.L., H.S., G.M.), NIH R01NS093213 (G.L.), R01MH105128 and R35NS097370 (G.M.), U19AI131130 (G.M., Z.W., H.T., and P.J.), U19MH106434, P01NS097206, R37NS047344 (H.S.), R21AI119530 (H.T.), NSF (China) (31430037), MOST (China) “973” program (2014CB942801/2012YQ03026006; Y.W., Z.X.), FSU Zika seed funding (H.T.), and by Adelson Medical Research Foundation (G.M.).

The authors (G.L., Y.O., G.M., H.S.) acknowledge the joint participation by the Adrienne Helis Malvin Medical Research Foundation.

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Neurosciences
  • Neurosciences & Neurology
  • EMBRYONIC STEM-CELLS
  • NEURAL CREST CELLS
  • IDENTIFICATION
  • PROGENITORS
  • DERIVATION
  • EXPOSURE
  • MODELS
  • BRAIN

Zika virus directly infects peripheral neurons and induces cell death

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Journal Title:

Nature Neuroscience

Volume:

Volume 20, Number 9

Publisher:

, Pages 1209-+

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Zika virus (ZIKV) infection is associated with neurological disorders of both the CNS and peripheral nervous systems (PNS), yet few studies have directly examined PNS infection. Here we show that intraperitoneally or intraventricularly injected ZIKV in the mouse can infect and impact peripheral neurons in vivo. Moreover, ZIKV productively infects stem-cell-derived human neural crest cells and peripheral neurons in vitro, leading to increased cell death, transcriptional dysregulation and cell-type-specific molecular pathology.

Copyright information:

© 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.

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