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Author Notes:

E-mail: dcutler@genetics.emory.edu

Conceived and designed the experiments: DJC HRJ.

Performed the experiments: DJC HRJ.

Analyzed the data: DJC HRJ.

Contributed reagents/materials/analysis tools: DJC HRJ.

Wrote the paper: DJC HRJ.

Michael Edward Zwick, Editor

We thank A Locke and Y Jakubek for informative discussions and F Spencer, A McCallion, A Chakravarti and J Mendell for helpful suggestions.

The authors have declared that no competing interests exist.

Subject:

Research Funding:

This work was supported by a grant from the NIH (National Institutes of Health) to D Cutler (5R01HG003461-05).

The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Keywords:

  • Science & Technology
  • Multidisciplinary Sciences
  • Science & Technology - Other Topics
  • RECOMBINATION HOTSPOTS
  • MEIOTIC RECOMBINATION
  • PRDM9
  • INSTABILITY
  • SPOT
  • MAP

A Comprehensive Search for Recombinogenic Motifs in the Human Genome

Tools:

Journal Title:

PLoS ONE

Volume:

Volume 8, Number 4

Publisher:

, Pages e62920-e62920

Type of Work:

Article | Final Publisher PDF

Abstract:

The patterns of male and female recombination vary greatly on a macro scale. A unique motif in each gender, triggering a double strand break at its location, much in the way Chi sites operate in E. coli, could logically explain this difference. As such, we have undertaken a comprehensive search of all small motifs in an attempt to identify one or more that match to the available data. In the end, we conclude that no such motifs appear to exist in the human genome.

Copyright information:

© 2013 Johnston, Cutler.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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