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Author Notes:

To whom correspondence should be addressed: Rollins Research Ctr., Rm. 5113, 1510 Clifton Rd., Emory University School of Medicine, Atlanta, GA 30322., Tel.: 404-727-3699; Fax: 404-727-0365; E-mail: rhall@pharm.emory.edu

We thank Luke Hartstein and William Watkins for technical support and Sarah Cork for helpful discussion.

Subjects:

Research Funding:

This work was supported in part by National Institutes of Health Grants NS072394 (to R. A. H.) and CA086335 and CA163722 (to E. G. V. M.).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Biochemistry & Molecular Biology
  • PROTEIN-COUPLED RECEPTORS
  • EMERGING ROLES
  • ADHESION-GPCRS
  • ENGULFMENT RECEPTOR
  • APOPTOTIC CELLS
  • BETA-ARRESTINS
  • BAI1
  • FAMILY
  • GENE
  • SCAFFOLD

Brain-specific Angiogenesis Inhibitor-1 Signaling, Regulation, and Enrichment in the Postsynaptic Density

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Journal Title:

Journal of Biological Chemistry

Volume:

Volume 288, Number 31

Publisher:

, Pages 22248-22256

Type of Work:

Article | Final Publisher PDF

Abstract:

Background: BAI1 is an adhesion receptor; little is known about its signaling or localization. Results: BAI1 activates Rho in a G protein-dependent manner, binds to synaptic scaffold proteins, and is highly enriched in the postsynaptic density. Conclusion: BAI1 is a synaptic receptor that signals through G proteins. Significance: BAI1 may play a previously unappreciated role as a regulator of synaptic function.

Copyright information:

© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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