Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO)

• Authors: Ai-Ming Yu, University of California Davis; Magnus Ingelman-Sundberg, Karolinska Institutet; Nathan J. Cherrington, University of Arizona; Lauren M. Aleksunes, Rutgers State University; Ulrich M. Zanger, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology; Wen Xie, University of Pittsburgh; Hyunyoung Jeong, University of Illinois; Edward T Morgan, Emory University; Peter J. Turnbaugh, University of California San Francisco; Curtis D. Klaassen, University of Washington; Aadra P. Bhatt, University of North Carolina Chapel Hill; Matthew R. Redinbo, University of North Carolina Chapel Hill; Pengying Hao, Boston University; David J. Waxman, Boston University; Li Wang, University of Connecticut; Xiao-bo Zhong, University of Connecticut
• Proceedings Title: Acta Pharmaceutica Sinica B
• Conference Name: 21st International Symposium on Microsomes and Drug Oxidations (MDO)
• Publisher: Institute of Materia Medica, Chinese Academy of Medical Sciences
• Conference Place: Netherlands
• Volume/Issue: Volume 7 | Issue 2
• Publication Date: 2017-03-01
• Type of Work: Conference | Final Publisher PDF
• Publisher DOI: http://doi.org/10.1016/j.apsb.2016.12.006
• Subjects: Health Sciences, Pharmacology; Health Sciences, Immunology
• Keywords: Science & Technology; Life Sciences & Biomedicine; Pharmacology & Pharmacy; Drug metabolism toxicity; Genetics.; Epigenetics; Gut microbiota; Long non-coding RNAs; Disease; Personalized medication; BILE-ACID PATHWAYS; ADULT-MOUSE LIVER; GERM-FREE MICE; PREGNANT MICE; ESTROGEN SULFOTRANSFERASE; SEX-DIFFERENCES; GROWTH-HORMONE; POTENTIAL ROLE; EXPRESSION; ENZYMES

Abstract

Variations in drug metabolism may alter drug efficacy and cause toxicity; better understanding of the mechanisms and risks shall help to practice precision medicine. At the 21 st International Symposium on Microsomes and Drug Oxidations held in Davis, California, USA, in October 2–6, 2016, a number of speakers reported some new findings and ongoing studies on the regulation mechanisms behind variable drug metabolism and toxicity, and discussed potential implications to personalized medications. A considerably insightful overview was provided on genetic and epigenetic regulation of gene expression involved in drug absorption, distribution, metabolism, and excretion (ADME) and drug response. Altered drug metabolism and disposition as well as molecular mechanisms among diseased and special populations were presented. In addition, the roles of gut microbiota in drug metabolism and toxicology as well as long non-coding RNAs in liver functions and diseases were discussed. These findings may offer new insights into improved understanding of ADME regulatory mechanisms and advance drug metabolism research.