Link Protein N-terminal Peptide Binds to Bone Morphogenetic Protein (BMP) Type II Receptor and Drives Matrix Protein Expression in Rabbit Intervertebral Disc Cells

Zili Wang; M. Neale Weitzmann; Dr. Sreedhara Sangadala; William C Hutton; Sangwook Yoon

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To whom correspondence should be addressed: Atlanta VA Medical Center, Research Bldg., Rm. 4A-189, 1670 Clairmont Rd., Decatur, GA 30033., Tel.: 404-694-9603; Fax: 404-728-7780; E-mail: zwang084@gmail.com or zwang2@emory.edu

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Research Funding:

Supported by Grant 5I01BX000105 from the Biomedical Laboratory Research and Development Service of the Veterans Affairs Office of Research and Development and National Institutes of Health Awards R01AR059364 through the NIAMS and R01AG040013 through the NIA.

This work was supported by Atlanta Research and Education Foundation, Atlanta Veterans Affairs Medical Center (to S. T. Y.).

Keywords:

Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
LOW-BACK-PAIN
CARTILAGE PROTEOGLYCANS
EXTRACELLULAR-MATRIX
ARTICULAR-CARTILAGE
NUCLEUS PULPOSUS
IN-VITRO
DEGENERATION
SOX9
GROWTH
BIOSYNTHESIS

Link Protein N-terminal Peptide Binds to Bone Morphogenetic Protein (BMP) Type II Receptor and Drives Matrix Protein Expression in Rabbit Intervertebral Disc Cells

Zili Wang, Emory University

M. Neale Weitzmann, Emory University

Dr. Sreedhara Sangadala, Emory University

William C Hutton, Emory University

Sangwook Yoon, Emory University

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Journal Title:

Journal of Biological Chemistry

Volume:

Volume 288, Number 39

Publisher:

American Society for Biochemistry and Molecular Biology | 2013-09-27, Pages 28243-28253

Type of Work:

Article | Final Publisher PDF

Permanent URL:

https://pid.emory.edu/ark:/25593/s75m8

Publisher DOI:

http://doi.org/10.1074/jbc.M113.451948

Abstract:

Background: LPP induces synthesis of aggrecan and collagen II; however, the mechanism is unknown. Results: LPP up-regulated expression of aggrecan, collagen II, and SOX9 through binding to BMP-RII, initiating a complex Smad/BMP feedforward circuit. Conclusion: LPP could promote disc matrix production directly or boost the activity of exogenous BMPs. Significance: LPP may have value in the treatment of degenerated discs.

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Keywords:

Link Protein N-terminal Peptide Binds to Bone Morphogenetic Protein (BMP) Type II Receptor and Drives Matrix Protein Expression in Rabbit Intervertebral Disc Cells

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