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Author Notes:

To whom correspondence should be addressed: Atlanta VA Medical Center, Research Bldg., Rm. 4A-189, 1670 Clairmont Rd., Decatur, GA 30033., Tel.: 404-694-9603; Fax: 404-728-7780; E-mail: zwang084@gmail.com or zwang2@emory.edu

Subjects:

Research Funding:

Supported by Grant 5I01BX000105 from the Biomedical Laboratory Research and Development Service of the Veterans Affairs Office of Research and Development and National Institutes of Health Awards R01AR059364 through the NIAMS and R01AG040013 through the NIA.

This work was supported by Atlanta Research and Education Foundation, Atlanta Veterans Affairs Medical Center (to S. T. Y.).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Biochemistry & Molecular Biology
  • LOW-BACK-PAIN
  • CARTILAGE PROTEOGLYCANS
  • EXTRACELLULAR-MATRIX
  • ARTICULAR-CARTILAGE
  • NUCLEUS PULPOSUS
  • IN-VITRO
  • DEGENERATION
  • SOX9
  • GROWTH
  • BIOSYNTHESIS

Link Protein N-terminal Peptide Binds to Bone Morphogenetic Protein (BMP) Type II Receptor and Drives Matrix Protein Expression in Rabbit Intervertebral Disc Cells

Tools:

Journal Title:

Journal of Biological Chemistry

Volume:

Volume 288, Number 39

Publisher:

, Pages 28243-28253

Type of Work:

Article | Final Publisher PDF

Abstract:

Background: LPP induces synthesis of aggrecan and collagen II; however, the mechanism is unknown. Results: LPP up-regulated expression of aggrecan, collagen II, and SOX9 through binding to BMP-RII, initiating a complex Smad/BMP feedforward circuit. Conclusion: LPP could promote disc matrix production directly or boost the activity of exogenous BMPs. Significance: LPP may have value in the treatment of degenerated discs.

Copyright information:

© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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