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Author Notes:

To whom correspondence should be addressed. Tel.: 404-727-3561; E-mail: rkahn@emory.edu

We thank Victor Faundez (Emory University) and Elizabeth Sztul (University of Alabama at Birmingham) for reading versions of the manuscript and providing critical feedback.

We gratefully acknowledge Gary Thomas (Oregon Health and Science University) and Margaret Robinson and Matthew Seaman (University of Cambridge) for sharing their plasmids and/or cell lines and Antonella De Matteis (Telethon Institute of Genetics and Medicine) and Juan Bonifacino (National Institutes of Health, NICHD) for their generous gifts of the FAPP2 and AP-4 antibodies, respectively.

Subjects:

Research Funding:

This work was supported, in whole or in part, by National Institutes of Health Grant R01 GM067226 from NIGMS and Grant P30 NS055077 (Imaging Core of the Emory Neuroscience NINDS Core Facilities).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Biochemistry & Molecular Biology
  • Adaptor Proteins
  • Amyloid Precursor Protein
  • Golgi
  • Lysosomes
  • Membrane Trafficking
  • ADP-ribosylation Factor
  • Mint3
  • Recycling Endosomes
  • ALZHEIMERS-DISEASE
  • BREFELDIN-A
  • COAT PROTEINS
  • ENDOPLASMIC-RETICULUM
  • TRAFFICKING PATHWAYS
  • MEMBRANE-TRANSPORT
  • DEPENDENT ADAPTER
  • CELL BIOLOGY
  • BETA-PROTEIN
  • NETWORK

Recruitment of the Mint3 Adaptor Is Necessary for Export of the Amyloid Precursor Protein (APP) from the Golgi Complex

Tools:

Journal Title:

Journal of Biological Chemistry

Volume:

Volume 288, Number 40

Publisher:

, Pages 28567-28580

Type of Work:

Article | Final Publisher PDF

Abstract:

Background:Traffic of the amyloid precursor protein (APP) determines its processing to neurotoxic Aβ peptides. Results:Mint3 is recruited to the Golgi by APP and is required for export to a LAMP1 + compartment. Conclusion:Mint3 and a LAMP1 + compartment are important components in APP traffic. Significance:Mint3 is an essential component in normal APP traffic with the potential to shift the balance in Aβ generation.

Copyright information:

© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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