About this item:

133 Views | 78 Downloads

Author Notes:

Correspondence: Sean R Stowell Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, United States srstowe@emory.edu

Subjects:

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Biochemistry & Molecular Biology
  • Biophysics
  • CARBOHYDRATE MICROARRAYS
  • BINDING-SPECIFICITY
  • HIV GLYCOBIOLOGY
  • SIALIC ACIDS
  • RECOGNITION
  • RECEPTOR
  • REVEALS
  • ANTIBODIES
  • OLIGOSACCHARIDE
  • PROTEINS

Using glycan microarrays to understand immunity

Tools:

Journal Title:

Current Opinion in Chemical Biology

Volume:

Volume 18, Number 1

Publisher:

, Pages 55-61

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Host immunity represents a complex array of factors that evolved to provide protection against potential pathogens. While many factors regulate host immunity, glycan binding proteins (GBPs) appear to play a fundamental role in orchestrating this process. In addition, GBPs also reside at the key interface between host and pathogen. While early studies sought to understand GBP glycan binding specificity, limitations in the availability of test glycans made it difficult to elucidate a detailed understanding of glycan recognition. Recent developments in glycan microarray technology revolutionized analysis of GBP glycan interactions with significant implications in understanding the role of GBPs in host immunity. In this review, we explore different glycan microarray formats with a focus on the impact of these arrays on understanding the binding specificity and function of GBPs involved in immunity.

Copyright information:

© 2014.

Export to EndNote