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Author Notes:

G. Chen gchen3@emory.edu

The authors would like to thank Dr. Jeff M. Sands from Renal Division, Emory University School of Medicine for the language review of this paper.

The authors declare that they do not have any conflict of interest.

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent is not applicable to this article.

Subjects:

Research Funding:

The related research was supported by NIH grants R01-DK087838 to Dr. Guangping Chen.

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Oncology
  • Urothelium
  • Cancer
  • Urea transporter
  • Gene expression
  • GENOME-WIDE ASSOCIATION
  • INVASIVE BLADDER-CANCER
  • POTENTIAL THERAPEUTIC TARGET
  • UREA TRANSPORTER GENE
  • CELL-CYCLE CONTROL
  • KIDD BLOOD-GROUP
  • UT-B
  • TRANSCRIPTION FACTORS
  • CONCENTRATING DEFECT
  • MOLECULAR-MECHANISMS

SLC14A1: a novel target for human urothelial cancer

Tools:

Journal Title:

Clinical and Translational Oncology

Volume:

Volume 19, Number 12

Publisher:

, Pages 1438-1446

Type of Work:

Article | Final Publisher PDF

Abstract:

Urinary bladder cancer is the second commonly diagnosed genitourinary malignancy. Previously, bio-molecular alterations have been observed within certain locations such as chromosome 9, retinoblastoma gene and fibroblast growth factor receptor-3. Solute carrier family 14 member 1 (SLC14A1) gene encodes the type-B urea transporter (UT-B) which facilitates the passive movement of urea across cell membrane, and has recently been related with human malignancies, especially for bladder cancer. Herein, we discussed the SLC14A1 gene and UT-B protein properties, aiming to elucidate the expression behavior of SLC14A1 in human bladder cancer. Furthermore, by reviewing some well-established theories regarding the carcinogenesis of bladder cancer, including several genome wide association researches, we have bridged the mechanisms of cancer development with the aberrant expression of SLC14A1. In conclusion, the altered expression of SLC14A1 gene in human urothelial cancer may implicate its significance as a novel target for research.

Copyright information:

© 2017, The Author(s).

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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