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  • Science & Technology
  • Life Sciences & Biomedicine
  • Virology

GM-CSF co-expressing DNA/MVA vaccine, prevention of acquisition by two series of SIVE660 challenges followed by a series of SIV251 challenges


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From AIDS Vaccine 2012 Boston, MA, USA. 9-12 September 2012

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In 2010 we reported prevention of acquisition of a repeated SIVE660 challenge in rhesus macaques vaccinated with a SIV239 DNA/MVA vaccine that co-expressed GM-CSF and VLP in the DNA prime. The reduced risk of infection correlated with the avidity of Env-specific IgG. Here we report studies on the longevity and breadth of this protective response.

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©2012 Robinson et al; licensee BioMed Central Ltd.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 2.0 Generic License (http://creativecommons.org/licenses/by/2.0/).

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