Multistep Conformation Selection in Amyloid Assembly.

• Authors: Ming-Chien Hsieh, Georgia Institute of Technology; Chen Liang, Emory University; Anil K. Mehta, Emory University; David Lynn, Emory University; Martha A. Grover, Georgia Institute of Technology
• Journal Title: Journal of the American Chemical Society
• Volume: Volume 139, Number 47
• Publisher: American Chemical Society | 2017-11-15, Pages 17007-17010
• Type of Work: Article | Final Publisher PDF
• Publisher DOI: http://doi.org/10.1021/jacs.7b09362
• Subjects: Chemistry, General; Chemistry, Analytical

Abstract

Defining pathways for amyloid assembly could impact therapeutic strategies for as many as 50 disease states. Here we show that amyloid assembly is subject to different forces regulating nucleation and propagation steps and provide evidence that the more global β-sheet/β-sheet facial complementarity is a critical determinant for amyloid nucleation and structural selection.