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Author Notes:

CORRESPONDING AUTHOR: Michele C. Walsh, M.D., M.S.Epi., Rainbow Babies & Children’s Hospital, 11100 Euclid Avenue, Suite RBC 3100, Cleveland, Ohio 44106-6010, Ph: 216-844-3759/, Fax: 216-844-3380, mcw3@case.edu.

See publication for full list of author contributions.

While NICHD staff did have input into the study design, conduct, analysis, and manuscript drafting, the content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

No financial or other conflicts.

Portions of the material in this manuscript were presented at the Pediatric Academic Society Meeting, May 2014, Vancouver BC, CA.


Research Funding:

The National Institutes of Health, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), and the National Center for Advancing Translational Sciences provided grant support for the Neonatal Research Network’s Moderately Preterm Registry through cooperative agreements.


  • Science & Technology
  • Life Sciences & Biomedicine
  • Pediatrics
  • CARE

Neonatal outcomes of moderately preterm infants compared to extremely preterm infants

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Journal Title:

Pediatric Research


Volume 82, Number 2


, Pages 297-304

Type of Work:

Article | Post-print: After Peer Review


BackgroundExtremely preterm infants (EPT, < 29 weeks' gestation) represent only 0.9% of births in the United States; yet these infants are the focus of most published research. Moderately preterm neonates (MPT, 29-33 6/7 weeks) are an understudied group of high-risk infants.MethodsTo determine the neonatal outcomes of MPT infants across the gestational age spectrum, and to compare these with EPT infants. A prospective observational cohort was formed in 18 level 3-4 neonatal intensive care units (NICUs) in the Eunice Kennedy Shriver NICHD Neonatal Research Network. Participants included all MPT infants admitted to NICUs and all EPT infants born at sites between January 2012 and November 2013. Antenatal characteristics and neonatal morbidities were abstracted from records using pre-specified definitions by trained neonatal research nurses.ResultsMPT infants experienced morbidities similar to, although at lower rates than, those of EPT infants. The main cause of mortality was congenital malformation, accounting for 43% of deaths. Central Nervous System injury occurred, including intraventricular hemorrhage. Most MPT infants required respiratory support, but sequelae such as bronchopulmonary dysplasia were rare. The primary contributors to hospitalization beyond 36 weeks' gestation were inability to achieve adequate oral intake and persistent apnea.ConclusionsMPT infants experience morbidity and prolonged hospitalization. Such morbidity deserves focused research to improve therapeutic and prevention strategies.

Copyright information:

© 2017 International Pediatric Research Foundation, Inc.

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