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Author Notes:

Correspondence to: Parvin Forghani, email: Parvin.forghani.esfahani@emory.edu

Correspondence to: Edmund K. Waller, email: ewaller@emory.edu

This research project was supported, in part, by the Winship Cancer Institute.

The authors would like to thank Dr. Andrea Pennati, Ph.D for his guidance in western blotting.

The authors declare no competing financial interests.

Subjects:

Research Funding:

This study was funded by a generous contribution from the Abraham J. & Phyllis Katz Foundation (PI: Waller).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Oncology
  • Cell Biology
  • CMV
  • myeloid-derived suppressor cells (MDSC)
  • VIP
  • mice
  • Immunology and Microbiology Section
  • Immune response
  • Immunity
  • VASOACTIVE-INTESTINAL-PEPTIDE
  • SUPPRESSOR-CELLS
  • TUMOR MICROENVIRONMENT
  • TROPHOBLAST CELLS
  • BREAST-CANCER
  • IMMUNOMODULATION
  • TOLERANCE
  • MODEL
  • MICE

Activation of VIP signaling enhances immunosuppressive effect of MDSCs on CMV-induced adaptive immunity

Tools:

Journal Title:

Oncotarget

Volume:

Volume 8, Number 47

Publisher:

, Pages 81873-81879

Type of Work:

Article | Final Publisher PDF

Abstract:

Vasoactive intestinal peptide (VIP) is recognized as a potent anti-inflammatory factor which affects both the innate and adaptive arms of the immune system. These effects include, but are not limited to, inhibition of T cell proliferation and disruption of immune homeostasis. Myeloid-derived suppressor cells (MDSC) are an immune regulatory cell type that has been described in settings of cancer and infectious disease. Here we demonstrate a reduced circulating monocytic MDSCs in the VIP -/- vs. wild type MCMV. VIP-/- MDSCs secretes less NO upon stimulation with LPS and interferon that relatively lose the ability to suppress T cells activation in vitro compared to wild type MDSCs. Considering the importance of VIP in immunomodulation, the possible effect of VIP in the suppressive function of MDSC populations following CMV infection remains unknown. We describe the possible role of VIP in the regulation of anti-CMV activity of T cells through the activation of MDSCs.

Copyright information:

© Forghani et al.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/).

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