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Author Notes:

Correspondence: avilessantal@nhlbi.nih.gov 1 Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 10188, Bethesda, MD 20892-7936, USA

MLAS, JH, NML, RGP, KR, ALAL, JB, AF, MAM, EM, GP, ILP, JP, SFS, and MAV were speakers at workshop.

Each one of them contributed with the discussion following the workshop, and wrote different sections of the manuscript, including the recommendations.

MLAS organized and designed the manuscript.

All authors read and approved the final manuscript.

The authors would like to thank Laura Jacobson (New York City Department of Health and Mental Hygiene), Jean Lawrence, ScD (Kaiser Permanente Southern California), Barbara Christensen, RN (American College of Cardiology), Kevin Abbott, PhD (NIDDK), Lindsey Enewold, PhD (NCI), Eimear Kenny, PhD (Mount Sinai Icahn School of Medicine), Ed Ramos, PhD (National Institute on Biomedical Imaging and Bioengineering) for their valuable contributions to presentations and discussions.

The authors would also like to thank Sonia Arteaga, PhD (NHLBI), Silvia Dossmann (NHLBI), Lisa LaVange, PhD (FDA), Barbara Linder, MD (NIDDK), Martin Mendoza, MD, PhD (FDA), George Mensah, MD (NHLBI), Mollie Minear, PhD (NHLBI), Jeannie Olson, MD, MPH (NHLBI), Eliseo Pérez-Stable, MD (Director of the National Institute on Minority Health and Health Disparities), LaShawndra Price, PhD (NHLBI), Mona Puggal, MPH (NHLBI), Catalina Ramos, RN (NHLBI), Yanira Ruiz-Perdomo, FNP-BC (National Institute of Arthritis and Musculoskeletal and Skin Diseases), Kathryn Valeda (NHLBI), Barbara Wells, PhD (NHLBI) for their input, assistance or participation in different stages of the organization of this workshop, and Jeannie Olson (NHLBI) and Jill Pope (Kaiser Permanente Center for Health Research) for their assistance with the editing of this manuscript.

And our deepest appreciation to Mr. and Mrs. Cabrera for sharing their personal story as clinical trial participants.

The authors have no conflicts of interest to disclose.

The views expressed in this manuscript are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the U.S. Department of Health and Human Services.

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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Research Funding:

This workshop was co-funded by the NHLBI, NIDDK and the FDA.

Funds for publication of this manuscript were provided by NHLBI.

Personalized medicine and Hispanic health: improving health outcomes and reducing health disparities – a National Heart, Lung, and Blood Institute workshop report

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Journal Title:

BMC Proceedings

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Volume 11, Number S11

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Article | Final Publisher PDF

Abstract:

Persons of Hispanic/Latino descent may represent different ancestries, ethnic and cultural groups and countries of birth. In the U.S., the Hispanic/Latino population is projected to constitute 29% of the population by 2060. A personalized approach focusing on individual variability in genetics, environment, lifestyle and socioeconomic determinants of health may advance the understanding of some of the major factors contributing to the health disparities experienced by Hispanics/Latinos and other groups in the U.S., thus leading to new strategies that improve health care outcomes. However, there are major gaps in our current knowledge about how personalized medicine can shape health outcomes among Hispanics/Latinos and address the potential factors that may explain the observed differences within this heterogeneous group, and between this group and other U.S. demographic groups. For that purpose, the National Heart, Lung, and Blood Institute (NHLBI), in collaboration with the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and the Food and Drug Administration (FDA), held a workshop in which experts discussed (1) potential approaches to study medical treatments and health outcomes among Hispanics/Latinos and garner the necessary evidence to fill gaps of efficacy, effectiveness and safety of therapies for heart, lung, blood and sleep (HLBS) disorders and conditions--and their risk factors; (2) research opportunities related to personalized medicine to improve knowledge and develop effective interventions to reduce health disparities among Hispanics/Latinos in the U.S.; and (3) the incorporation of expanded sociocultural and socioeconomic data collection and genetic/genomic/epigenetic information of Hispanic/Latino patients into their clinical assessments, to account for individual variability in ancestry; physiology or disease risk; culture; environment; lifestyle; and socioeconomic determinants of health. The experts also provided recommendations on: sources of Hispanic/Latino health data and strategies to enhance its collection; policy; genetics, genomics and epigenetics research; and integrating Hispanic/Latino health research within clinical settings.

Copyright information:

© The Author(s). 2017

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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