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191 Views | 117 Downloads

Author Notes:

Corresponding author: rgross@emory.edu

Subject:

Research Funding:

This work was supported by NIH NS079268, NS079757, NS086433 and NSF 1512826.

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Clinical Neurology
  • Neurosciences
  • Neurosciences & Neurology
  • Optogenetics
  • Epilepsy
  • Neuromodulation
  • RESPONSIVE CORTICAL STIMULATION
  • CENTROMEDIAN THALAMIC NUCLEUS
  • VAGUS-NERVE-STIMULATION
  • DEEP BRAIN-STIMULATION
  • TEMPORAL-LOBE EPILEPSY
  • LONG-TERM
  • ELECTRICAL-STIMULATION
  • EPILEPTIFORM ACTIVITY
  • GENE-THERAPY
  • INTRACTABLE EPILEPSY

Optogenetic Approaches for Controlling Seizure Activity

Tools:

Journal Title:

Brain Stimulation

Volume:

Volume 9, Number 6

Publisher:

, Pages 801-810

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Optogenetics, a technique that utilizes light-sensitive ion channels or pumps to activate or inhibit neurons, has allowed scientists unprecedented precision and control for manipulating neuronal activity. With the clinical need to develop more precise and effective therapies for patients with drug-resistant epilepsy, these tools have recently been explored as a novel treatment for halting seizure activity in various animal models. In this review, we provide a detailed and current summary of these optogenetic approaches and provide a perspective on their future clinical application as a potential neuromodulatory therapy.

Copyright information:

© 2016 Elsevier Inc. All rights reserved.

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