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Author Notes:

E-mail: flegr@cesnet.cz

Conceived and designed the experiments: JF.

Analyzed the data: JF.

Contributed reagents/materials/analysis tools: JF.

Wrote the paper: JF JP ZI.

Data collection: MS.

The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Subjects:

Research Funding:

The authors’ work was supported by the Grand Agency of the Czech Republic (Grant No. P303/11/1398) and Charles University of Prague (grant UNCE 204004).

Keywords:

  • Science & Technology
  • Multidisciplinary Sciences
  • Science & Technology - Other Topics
  • ACQUIRED-IMMUNODEFICIENCY-SYNDROME
  • OBSESSIVE-COMPULSIVE DISORDER
  • GROWTH-FACTOR-BETA
  • CHRONIC MURINE TOXOPLASMOSIS
  • GRADE SYSTEMIC INFLAMMATION
  • CENTRAL DIABETES-INSIPIDUS
  • PRIMARY BILIARY-CIRRHOSIS
  • GONDII ANTIBODY-TITERS
  • INFANT-DEATH-SYNDROME
  • NATURAL-KILLER-CELLS

Toxoplasmosis - A Global Threat. Correlation of Latent Toxoplasmosis with Specific Disease Burden in a Set of 88 Countries

Tools:

Journal Title:

PLoS ONE

Volume:

Volume 9, Number 3

Publisher:

, Pages e90203-e90203

Type of Work:

Article | Final Publisher PDF

Abstract:

Background: Toxoplasmosis is becoming a global health hazard as it infects 30-50% of the world human population. Clinically, the life-long presence of the parasite in tissues of a majority of infected individuals is usually considered asymptomatic. However, a number of studies show that this 'asymptomatic infection' may also lead to development of other human pathologies. Aims of the Study: The purpose of the study was to collect available geoepidemiological data on seroprevalence of toxoplasmosis and search for its relationship with mortality and disability rates in different countries. Methods and Findings: Prevalence data published between 1995-2008 for women in child-bearing age were collected for 88 countries (29 European). The association between prevalence of toxoplasmosis and specific disease burden estimated with age-standardized Disability Adjusted Life Year (DALY) or with mortality, was calculated using General Linear Method with Gross Domestic Product per capita (GDP), geolatitude and humidity as covariates, and also using nonparametric partial Kendall correlation test with GDP as a covariate. The prevalence of toxoplasmosis correlated with specific disease burden in particular countries explaining 23% of variability in disease burden in Europe. The analyses revealed that for example, DALY of 23 of 128 analyzed diseases and disease categories on the WHO list showed correlations (18 positive, 5 negative) with prevalence of toxoplasmosis and another 12 diseases showed positive trends (p < 0.1). For several obtained significant correlations between the seroprevalence of toxoplasmosis and specific diseases/clinical entities, possible pathophysiological, biochemical and molecular explanations are presented. Conclusions: The seroprevalence of toxoplasmosis correlated with various disease burden. Statistical associations does not necessarily mean causality. The precautionary principle suggests however that possible role of toxoplasmosis as a triggering factor responsible for development of several clinical entities deserves much more attention and financial support both in everyday medical practice and future clinical research.

Copyright information:

This is an Open Access work distributed under the terms of the Creative Commons Universal : Public Domain Dedication License (http://creativecommons.org/publicdomain/zero/1.0/).

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