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Author Notes:

Zhiqiang Qu, Medical Research Center, Affiliated Hospital, Qingdao University, Qingdao 266555, China. Tel: 086-18661801173; Fax: 086-532-83780136; E-mail: 18661801173@163.com and Weicheng Yao, Department of Neurosurgery, Affiliated Hospital, Qingdao University, Qingdao 266555, China. E-mail: yaoweicheng888@163.com

Conflict of Interest: None declared.

Subjects:

Research Funding:

This study is supported by the National Natural Science Foundation of China (NSFC 30840004, 81070215 and 31371152) to ZQ.

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Oncology
  • ANO1
  • Ca2+-activated Cl- channel
  • cancer
  • cell proliferation
  • tumorigenesis
  • ACTIVATED CHLORIDE CHANNEL
  • GASTROINTESTINAL STROMAL TUMORS
  • NASOPHARYNGEAL CARCINOMA-CELLS
  • GASTRIC-CANCER CELLS
  • ION CHANNELS
  • BREAST-CANCER
  • TRANSCRIPTOME ANALYSIS
  • TRANSMEMBRANE PROTEIN
  • EPITHELIAL-CELLS
  • EXPRESSION

The Ca2+-activated Cl- channel, ANO1 (TMEM16A), is a double-edged sword in cell proliferation and tumorigenesis

Tools:

Journal Title:

Cancer Medicine

Volume:

Volume 3, Number 3

Publisher:

, Pages 453-461

Type of Work:

Article | Final Publisher PDF

Abstract:

Since anoctamin 1 ANO1 (TMEM16A) was found to be a molecular component of Ca(2+) -activated Cl(-) channels, its role in tumorigenesis has gained attention at a fast pace. ANO1 overexpression frequently occurs in the cancer tissues along with 11q13 chromosome amplification. Poor prognosis of many types of cancers has been closely correlated with ANO1 gene amplification and protein overexpression. ANO1 is now considered an excellent biomarker for certain cancers. Recent research suggests that it is the channel function of ANO1 that is involved in the tumorigenesis. However, how the overexpression of the functional ANO1 causes malignant transformation of tissues via signaling pathways, for example, MAPK remains to be investigated. Clarification of the reasons in future will avail to make ANO1 as a target for cancer treatment.

Copyright information:

© 2014 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/).

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