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Correspondence should be addressed to Katherine W. Roche, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 35, Room 2C-903, 9000 Rockville Pike, Bethesda, MD 20892-3704., rochek@ninds.nih.gov; and Stephen F. Traynelis, Department of Pharmacology and Center for Functional Evaluation of Rare Variants (CFERV), Emory University School of Medicine, Atlanta, GA 30322., strayne@emory.edu
Author contributions: H.Y., W.L., S.F.T., and K.W.R. designed research; S.L., L.Z., H.Y., M.V., and J.D.B. performed research; M.V., A.S.-C., J.D.B., W.L., S.F.T., and K.W.R. contributed unpublished reagents/analytic tools; S.L., L.Z., H.Y., M.V., A.S.-C., W.L., S.F.T., and K.W.R. analyzed data; S.L., L.Z., H.Y., M.V., A.S.-C., W.L., S.F.T., and K.W.R. wrote the paper.
We thank Jing Zhang and Phuong Le for technical assistance and the NINDS light imaging facility for their expertise.
S.F.T. is a consultant of Janssen Pharmaceuticals, Inc., Pfizer Inc, Boehringer Ingelheim Pharma GmbH & Co. KG, and co-founder of NeurOp Inc.
The other authors declare no competing financial interest.
This work was supported by the National Institute of Neurological Disorders and Stroke–National Institutes of Health (NINDS Intramural Program Grant to S.L., M.V., L.Z., A.S.-C., J.D.B., W.L. and K.W.R. and Grants NS036654 and NS092989 to S.F.T.), the Eunice Kennedy Shriver National Institute of Child Health and Human Development–NIH (Grant R01-HD082373 to H.Y.), the National Center for Advancing Translational Sciences–NIH (Grant UL1-TR000454 to H.Y.), the National Institute on Aging–NIH (Career Transition Award R00 AG041225 to A.S.-C.), and Portuguese Foundation for Science and Technology (FCT-Fundacao para a Ciencia e a Tecnologia, Grant SFRH/BI/106010/2015 to M.V.).
© 2017 the authors.