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Author Notes:

To whom correspondence should be addressed. E-mail: gmeliki@emory.edu.

Critical reading and helpful comments on the manuscript by the members of the Melikyan laboratory are greatly appreciated.

The author declares that he has no conflicts of interest with the contents of this article.

The content is solely the responsibility of the author and does not necessarily represent the official views of the National Institutes of Health.

Subjects:

Research Funding:

The HIV fusion work in the Melikyan laboratory is supported by the National Institutes of Health Grant R01 GM054787.

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Biochemistry & Molecular Biology

How entry inhibitors synergize to fight HIV

Tools:

Journal Title:

Journal of Biological Chemistry

Volume:

Volume 292, Number 40

Publisher:

, Pages 16511-16512

Type of Work:

Article | Final Publisher PDF

Abstract:

HIV fusion with the cell membrane can be inhibited by blocking coreceptor binding or by preventing fusion-inducing conformational changes in the Env protein. Logically, inhibitors that act by these two mechanisms should act synergistically, but previous studies have reported conflicting results. A new study by Ahn and Root reconciles these discordant reports by demonstrating that synergy emerges when Env engages multiple coreceptors prior to inducing fusion and when high-affinity inhibitory peptides are used, a condition that may not be satisfied in vivo.

Copyright information:

© 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

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