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To whom correspondence should be addressed. E-mail: richard.kitsis@einstein.yu.edu
Edited* by Andrew R. Marks, Columbia University College of Physicians and Surgeons, New York, NY, and approved March 9, 2012
Author contributions: R.S.W., K.K., J.W.C., T.L., C.B.T., M.T.C., E.G., G.W.D., B.O., and R.N.K. designed research;
R.S.W., K.K., A.-C.W., Y.C., D.E.R., S.J., Y.Y., J.W.C., and E.G. performed research;
T.L., C.B.T., M.T.C., and E.G. contributed new reagents/analytic tools;
R.S.W., K.K., A.-C.W., Y.C., Y.Y., J.W.C., G.W.D., B.O., and R.N.K. analyzed data;
and R.S.W., K.K., and R.N.K. wrote the paper.
We thank Drs. Emily H.-Y. Cheng and Xu Luo for constructs and cell lines, Drs. Nina Kaludercic and Fabio DiLisa for advice regarding mitochondrial assays, Drs. Charles J. Steenbergen and Stephen M. Factor for advice regarding cardiac pathology, and Chad K. Nicholson for technical assistance.
We also thank the Wilf family for their ongoing generosity and support.
The authors declare no conflict of interest.
This work was supported by Grants 5R01HL60665-13 (to R.N.K.), 5P30CA013330-39 (to R.N.K. and E.G.), 5P60DK020541-34 (to R.N.K.), 5R37HL054598-16 (to B.O.), 5R01HL059888-12 (to G.W.D.), 4R00HL095929-02 (to E.G.), American Heart Association Grant GRNT2290168 (to M.T.C.), 5T32AG023475-08 (to R.S.W.), and the A. G. Leventis Foundation (K.K.).
R.N.K. is supported by The Dr. Gerald and Myra Dorros Chair in Cardiovascular Disease.
© Whelan et al.