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To whom correspondence may be addressed. E-mail: lmiao@moon.ibp.ac.cn or dongmengqiu@nibs.ac.cn.
Author contributions: M.-Q.D. and L.M. designed research
Y.Z., W.S., P.Z., H.C., M.-J.Z., C.-Q.S., X.M., Y.S., B.W., Y.H., S.-M.H., M.-Q.D., and L.M. performed research
Z.H., A.F.H., S.W.L., and S.-M.H. contributed new reagents/analytic tools
Y.Z., W.S., P.Z., H.C., M.-J.Z., C.-Q.S., X.M., Y.S., B.W., Y.H., F.M., S.W.L., S.-M.H., M.-Q.D., and L.M. analyzed data
Y.Z., F.M., S.W.L., M.-Q.D., and L.M. wrote the paper.
We thank Dr. Li-Lin Du for valuable ideas regarding the BLAST search; Dr. Jian Ren for advice with Fig. 3F; Ning Yang for help with Fig. 1E; Gail Ekman for advice in degenerate PCR; Dr. Taotao Wei for providing various protease inhibitors; Drs. Hengbin Wang and Yixian Zheng for critically reading the manuscript; and Wei Zhuang for excellent technical assistance.
The authors declare no conflict of interest.
This research was supported by Grants 2012CB94502, 2010CB912303, and 30971648 (to L.M.), 2007AA02Z1A7 and 2010CB835203 (to M.-Q.D.), 2010CB912701 (to S.-M.H.), 30871226 and 31071180 (to Y.Z.) from the government of the People's Republic of China. L.M. is supported by the Chinese Academy of Sciences 100-Talents Program.
S.W.L. was supported by National Institutes of Health Grant GM082932.