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Author Notes:

Correspondence: Xiao-Tao Jin, Division of Neuroscience, Yerkes National Primate Research Center and Department of Neurology, Emory University, 954 Gatewood Road NE, Atlanta, GA 30322, USA. e-mail: jxiaota@emory.edu

Subjects:

Research Funding:

This research was supported by NIH grant RO1 NS 0432937 and the Yerkes Primate Center NIH base Grant (RR-00165). Thanks to Jean-Francois Pare and Xing Hu for technical assistance.

Keywords:

  • GABA transporter
  • globus pallidus
  • patch clamp recording
  • striatum
  • substantia nigra

Localization and function of GABA transporters GAT-1 and GAT-3 in the basal ganglia

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Journal Title:

Frontiers in Systems Neuroscience

Volume:

Volume 5, Number JULY 2011

Publisher:

, Pages 63-63

Type of Work:

Article | Final Publisher PDF

Abstract:

GABA transporter type 1 and 3 (GAT-1 and GAT-3, respectively) are the two main subtypes of GATs responsible for the regulation of extracellular GABA levels in the central nervous system. These transporters are widely expressed in neuronal (mainly GAT-1) and glial (mainly GAT-3) elements throughout the brain, but most dat a obt ained so far relate to their role in the regulation of GABA A receptor-mediated postsynaptic tonic and phasic inhibition in the hippocampus, cerebral cortex and cerebellum. Taking into consideration the key role of GABAergic transmission within basal ganglia networks, and the importance for these systems to be properly balanced to mediate normal basal ganglia function, we analyzed in detail the localization and function of GAT-1 and GAT-3 in the globus pallidus of normal and Parkinsonian animals, in order to further understand the substrate and pos sible mechanisms by which GABA transporters may regulate basal ganglia outfow, and may become relevant targets for new therapeutic approaches for the treatment of basal ganglia-related disorders. In this review, we describe the general features of GATs in the basal ganglia, and give a detailed account of recent evidence that GAT-1 and GAT-3 regulation can have a major impact on the fring rate and pattern of basal ganglia neurons through pre- and post-synaptic GABA A - and GABA B -receptor-mediated effects.

Copyright information:

© 2011 Jin, Galvan, Wichmann and Smith. This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.

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