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Author Notes:

Address correspondence to Emilia H. Koumans, ekoumans@cdc.gov

The findings and conclusions of this article are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention.

There are no conflicts regarding funding, employment, or financial interests.

Subjects:

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Microbiology
  • Pharmacology & Pharmacy
  • MICROBIOLOGY
  • PHARMACOLOGY & PHARMACY
  • PREVENT PRETERM DELIVERY
  • BACTERIAL VAGINOSIS
  • WOMEN
  • METAANALYSIS
  • TRICHOMONAS
  • ERYTHROMYCIN
  • WEIGHT
  • SAFETY
  • COHORT
  • TRIAL

Investigation of Metronidazole Use during Pregnancy and Adverse Birth Outcomes

Tools:

Journal Title:

Antimicrobial Agents and Chemotherapy

Volume:

Volume 56, Number 9

Publisher:

, Pages 4800-4805

Type of Work:

Article | Final Publisher PDF

Abstract:

To assess whether treatment with metronidazole during pregnancy is associated with preterm birth, low birth weight, or major congenital anomalies, we conducted chart reviews and an analysis of electronic data from a cohort of women delivering at an urban New York State hospital. Of 2,829 singleton/mother pairs, 922 (32.6%) mothers were treated with metronidazole for clinical indications, 348 (12.3%) during the first trimester of pregnancy and 553 (19.5%) in the second or third trimester. There were 333 (11.8%) preterm births, 262 (9.3%) infants of low birth weight, and 52 infants (1.8%) with congenital anomalies. In multi-variable analysis, no association was found between metronidazole treatment and preterm birth (odds ratio [OR], 1.02 [95% confidence interval [CI] , 0.80 to 1.32]), low birth weight (OR, 1.05 [95% CI, 0.77 to 1.43] ), or treatment in the first trimester and congenital anomalies (OR, 0.86 [0.30 to 2.45]). We found no association between metronidazole treatment during the first or later trimesters of pregnancy and preterm birth, low birth weight, or congenital anomalies.

Copyright information:

© 2012, American Society for Microbiology. All Rights Reserved.

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