About this item:

110 Views | 104 Downloads

Author Notes:

Address correspondence to: Ravi Mangal Patel, Division of Neonatal-Perinatal Medicine, Emory University School of Medicine, 2015, Uppergate Dr. NE, 3rd floor, Atlanta, GA 30322, USA, Tel.: +1-404-727-5905, rmpatel@emory.edu

We appreciate the input and critical review of portions of this work by Mary A.M. Rogers, Ph.D., M.S. (University of Michigan), Donald M. Mock, M.D., Ph.D. (University of Arkansas for Medical Sciences), Ronald G. Strauss, M.D., (University of Iowa), Patrick D. Carroll M.D., M.P.H. (Intermountain Healthcare), Edward Bell, M.D. (University of Iowa), Cassandra Josephson, M.D. (Emory University), and Jeanne Hendrickson, M.D. (Yale University).

Ravi M. Patel and Erin K. Meyer have no potential conflicts of interest for this publication.

John A. Widness serves on the scientific advisory board for HemoGenix Corporation.


Research Funding:

This publication was supported in part by US Public Health Service National Institutes of Health Grants P01 HL046925 (J.A.W), KL2 TR000455 (R.M.P), UL1 TR000454 (R.M.P), K23 HL128942 (R.M.P) and by the Thrasher Research Fund 0285-3 (J.A.W.).


  • Science & Technology
  • Life Sciences & Biomedicine
  • Hematology
  • Infant
  • Newborn
  • Prematurity, blood bank
  • Hemoglobin
  • Anemia

Research Opportunities to Improve Neonatal Red Blood Cell Transfusion


Journal Title:

Transfusion Medicine Reviews


Volume 30, Number 4


, Pages 165-173

Type of Work:

Article | Post-print: After Peer Review


Red blood cell (RBC) transfusion is a common and lifesaving therapy for anemic neonates and infants, particularly among those born prematurely or undergoing surgery. However, evidence-based indications for when to administer RBCs and adverse effects of RBC transfusion on important outcomes including necrotizing enterocolitis, survival, and long-term neurodevelopmental impairment remain uncertain. In addition, blood-banking practices for preterm and term neonates and infants have been largely developed using studies from older children and adults. Use of and refinements in emerging technologies and advances in biomarker discovery and neonatal-specific RBC transfusion databases may allow clinicians to better define and tailor RBC transfusion needs and practices to individual neonates. Decreasing the need for RBC transfusion and developing neonatal-specific approaches in the preparation of donor RBCs have potential for reducing resource utilization and cost, improving outcomes, and assuring blood safety. Finally, large donor-recipient–linked cohort studies can provide data to better understand the balance of the risks and benefits of RBC transfusion in neonates. These studies may also guide the translation of new research into best practices that can rapidly be integrated into routine care. This review highlights key opportunities in transfusion medicine and neonatology for improving the preparation and transfusion of RBCs into neonates and infants. We focus on timely, currently addressable knowledge gaps that can increase the safety and efficacy of preterm and term neonatal and infant RBC transfusion practices.

Copyright information:

© 2016 Elsevier Inc.

Export to EndNote