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Author Notes:

Correspondence to H.S.: shongju1@jhmi.edu

The authors apologize to colleagues whose work was not cited owing to space limitations.

The authors declare no competing interests.

Subjects:

Research Funding:

This work is supported by the US National Institutes of Health (NIH; NS047344 and HD086820 to H.S., NS048271, NS095348, MH110160 and MH105128 to G.L.M., NS051630, NS079625 and MH102690 to P.J.), Dr. Miriam & Sheldon G. Adelson Medical Research Foundation (to G.L.M.) and the Howard Hughes Medical Institute (to C.H.).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Neurosciences
  • Neurosciences & Neurology
  • NEURAL STEM-CELLS
  • NUCLEAR RECEPTOR TLX
  • REGULATES NEURONAL DIFFERENTIATION
  • ADULT HIPPOCAMPAL NEUROGENESIS
  • DNA METHYLTRANSFERASES DNMT3A
  • GENE-EXPRESSION REGULATION
  • R6/2 MOUSE MODEL
  • ALZHEIMERS-DISEASE
  • HUNTINGTONS-DISEASE
  • ALPHA-SYNUCLEIN
  • Adult neurogenesis
  • Developmental neurogenesis
  • Diseases of the nervous system
  • Epigenetics in the nervous system

Epigenetic mechanisms in neurogenesis

Tools:

Journal Title:

Nature Reviews Neuroscience

Volume:

Volume 17, Number 9

Publisher:

, Pages 537-549

Type of Work:

Article | Post-print: After Peer Review

Abstract:

In the embryonic and adult brain, neural stem cells proliferate and give rise to neurons and glia through highly regulated processes. Epigenetic mechanisms-including DNA and histone modifications, as well as regulation by non-coding RNAs-have pivotal roles in different stages of neurogenesis. Aberrant epigenetic regulation also contributes to the pathogenesis of various brain disorders. Here, we review recent advances in our understanding of epigenetic regulation in neurogenesis and its dysregulation in brain disorders, including discussion of newly identified DNA cytosine modifications. We also briefly cover the emerging field of epitranscriptomics, which involves modifications of mRNAs and long non-coding RNAs.

Copyright information:

© 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.

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