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Research Funding:

This review article was supported by Department of Health and Human Services (National Institutes of Health Grant 5R01- DK067110 to He-Ping Ma).

Scanning ion conductance microscopy: a nanotechnology for biological studies in live cells


Journal Title:

Frontiers in Physiology


Volume 3, Number 483


, Pages 1-6

Type of Work:

Article | Final Publisher PDF


Scanning ion-conductance microscope (SICM), which enables high-resolution imaging of cell surface topography, has been developed for over two decades. However, only recently, a unique scanning mode is increasingly used in biological studies to allow SICM to detect the surface of live cells. More recently, in combination with confocal microscopy and patch-clamp electrophysiological techniques, SICM allows investigators to localize proteins or ion channels in a specific nanostructure at the cell surface. This article will briefly review SICM nanotechnique and summarize the role of SICM in biological studies.

Copyright information:

© 2013 Liu, Lu, Song, Lei, Alli, Bao, Eaton and Ma.

This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License ( http://creativecommons.org/licenses/by/3.0/), which permits making multiple copies, distribution of derivative works, distribution, public display, and publicly performance, provided the original work is properly cited. This license requires credit be given to copyright holder and/or author, copyright and license notices be kept intact.

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