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Author Notes:

Corresponding author: Kathleen M. Egan, ScD, Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, MRC-CANCONT, Tampa, FL 33612-9416, P: 813-745-6149, F: 813-745-6525, Kathleen.Egan@moffitt.org

The authors wish to acknowledge the study participants and their families.

We further wish to thank the clinicians and research staffs at participating medical centers for their contributions.

In addition, we acknowledge Harold Colbassani, MD; Dean Gobo, MD; and Christopher Mickler, DO at Morton Plant Mease Healthcare and Baycare Health System in Clearwater, FL for their efforts recruiting subjects to the study.

The authors declare no conflicts of interest.

Subjects:

Research Funding:

The project was supported by the National Institutes of Health (R01CA116174) and institutional funding provided by the Moffitt Cancer Center (Tampa, FL) and the Vanderbilt-Ingram Comprehensive Cancer Center (Nashville, TN).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Public, Environmental & Occupational Health
  • Glioma
  • Glioblastoma
  • Risk
  • Prevention
  • Aspirin
  • Nonsteroidal anti-inflammatory agents
  • Case-control study
  • Epidemiology
  • NONSTEROIDAL ANTIINFLAMMATORY DRUGS
  • LOW-DOSE ASPIRIN
  • NERVOUS-SYSTEM TUMORS
  • CYCLOOXYGENASE-2 EXPRESSION
  • 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE
  • PROGNOSTIC-SIGNIFICANCE
  • CANCER PREVENTION
  • COLORECTAL-CANCER
  • MENINGIOMA RISK
  • MEDICATION USE

Analgesic use and the risk of primary adult brain tumor

Tools:

Journal Title:

European Journal of Epidemiology

Volume:

Volume 31, Number 9

Publisher:

, Pages 917-925

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Glioma and meningioma are uncommon tumors of the brain with few known risk factors. Regular use of aspirin has been linked to a lower risk of gastrointestinal and other cancers, though evidence for an association with brain tumors is mixed. We examined the association of aspirin and other analgesics with the risk of glioma and meningioma in a large US case–control study. Cases were persons recently diagnosed with glioma or meningioma and treated at medical centers in the southeastern US. Controls were persons sampled from the same communities as the cases combined with friends and other associates of the cases. Information on past use of analgesics (aspirin, other anti-inflammatory agents, and acetaminophen) was collected in structured interviews. Logistic regression was used to estimate odds ratios (ORs) and 95 % confidence intervals (CIs) for analgesic use adjusted for potential confounders. All associations were considered according to indication for use. A total of 1123 glioma cases, 310 meningioma cases and 1296 controls were included in the analysis. For indications other than headache, glioma cases were less likely than controls to report regular use of aspirin (OR 0.69; CI 0.56, 0.87), in a dose-dependent manner (P trend  <  0.001). No significant associations were observed with other analgesics for glioma, or any class of pain reliever for meningioma. Results suggest that regular aspirin use may reduce incidence of glioma.

Copyright information:

© 2016, Springer Science+Business Media Dordrecht.

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