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Author Notes:

Ramkumar Menon, Department of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine Perinatal Research, The University of Texas Medical Branch at Galveston, Galveston, TX, USA. E-mail: ram.menon@utmb.edu

The authors have stated explicitly that there are no conflicts of interest in connection with this article.

Subjects:

Research Funding:

The series and this work are supported in part by the National Institute of Health Reproductive, Perinatal, and Pediatric Health Training grant T32 HD052460.

This article followed from a four-part seminar series on causes of racial disparities in PTB held in the autumn of 2009 at the Rollins School of Public Health, Emory University (Atlanta, GA, USA).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Obstetrics & Gynecology
  • OBSTETRICS & GYNECOLOGY
  • African-American
  • health disparity
  • micronutrients
  • nutritional deficiency
  • pregnancy outcome
  • preterm birth
  • women's health
  • RANDOMIZED CONTROLLED-TRIALS
  • NUTRITION EXAMINATION SURVEY
  • POLYUNSATURATED FATTY-ACIDS
  • FOLIC-ACID
  • BACTERIAL VAGINOSIS
  • PREGNANCY OUTCOMES
  • PROSPECTIVE COHORT
  • AFRICAN-AMERICAN
  • IRON-DEFICIENCY
  • VITAMIN-D

Racial disparities in preterm birth: an overview of the potential role of nutrient deficiencies

Tools:

Journal Title:

Acta Obstetricia et Gynecologica Scandinavica

Volume:

Volume 90, Number 12

Publisher:

, Pages 1332-1341

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Objective. To give an overview of the literature for evidence of nutrient deficiencies as contributors to the disparity in preterm birth (PTB) between African-American and Caucasian women. Design. Structured literature survey. Methods. We searched MEDLINE to identify observational and experimental studies that evaluated the relation between nutrient intake and/or supplementation and PTB. For nutrients for which studies supported an association, we searched MEDLINE for studies of the prevalence of deficiency in the USA by race. Main Outcome Measures. Summarized findings on nutrients for which there is both evidence of a role in PTB and variability in t he prevalence of deficiency by race. Results. Nutrient deficiencies for which there are varying levels of evidence for an association with PTB and a greater burden among African-American compared with Caucasian women include deficiencies of iron, folic acid, zinc, vitamin D, calcium and magnesium, and imbalance of ω-3 and ω-6 polyunsaturated fatty acids. There are inadequate high-quality studies that investigate the role of nutrient deficiencies in PTB, their potential interaction with other risks, the proportion of excess risk for which they account, and whether supplementation can reduce the risk of, and racial disparities in, PTB in US populations. Conclusion. Deficiencies of several nutrients have varying levels of evidence of association with PTB and are of greater burden among African-American compared with Caucasian women. Although further research is needed, strategies that improve the nutritional status of African-American women may be a means of addressing a portion of the racial disparity in PTB. © 2011 Nordic Federation of Societies of Obstetrics and Gynecology.

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