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Author Notes:

Correspondence: James Q. Zheng, Department of Cell Biology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322. james.zheng@emory.edu

Conflict of Interest Statement: Nothing declared.

Subject:

Research Funding:

The work is partially supported by research grants from National Institutes of Health to JQZ (GM083889 and MH104632), F32 fellowship to KRM (NS092342), and a F31 fellowship to OFO (NS092437).

Keywords:

  • Science & Technology
  • Life Sciences & Biomedicine
  • Neurosciences
  • Neurosciences & Neurology
  • AMPA RECEPTOR TRAFFICKING
  • LONG-TERM POTENTIATION
  • SYNAPTIC PLASTICITY
  • NUCLEATION FACTOR
  • CAPPING PROTEIN
  • ARP2/3 COMPLEX
  • BETA-ADDUCIN
  • MOLECULAR-MECHANISMS
  • DYNAMICS
  • MORPHOGENESIS

Actin cytoskeleton in dendritic spine development and plasticity

Tools:

Journal Title:

Current Opinion in Neurobiology

Volume:

Volume 39

Publisher:

, Pages 86-92

Type of Work:

Article | Post-print: After Peer Review

Abstract:

Synapses are the basic unit of neuronal communication and their disruption is associated with many neurological disorders. Significant progress has been made towards understanding the molecular and genetic regulation of synapse formation, modulation, and dysfunction, but the underlying cellular mechanisms remain incomplete. The actin cytoskeleton not only provides the structural foundation for synapses, but also regulates a diverse array of cellular activities underlying synaptic function. Here we will discuss the regulation of the actin cytoskeleton in dendritic spines, the postsynaptic compartment of excitatory synapses. We will focus on a select number of actin regulatory processes, highlighting recent advances, the complexity of crosstalk between different pathways, and the challenges of understanding their precise impact on the structure and function of synapses.

Copyright information:

© 2016 Elsevier Ltd.

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