Interleukin 1 alpha and the inflammatory process

• Authors: Nelson Di Paolo, Emory University; Dmitry Shayakhmetov, Emory University
• Journal Title: Nature Immunology
• Volume: Volume 17, Number 8
• Publisher: Nature Publishing Group | 2016-07-19, Pages 906-913
• Type of Work: Article | Post-print: After Peer Review
• Publisher DOI: http://doi.org/10.1038/ni.3503
• Subjects: Health Sciences, Immunology
• Keywords: Science & Technology; Life Sciences & Biomedicine; Immunology; SYSTEMIC-SCLEROSIS FIBROBLASTS; PANCREATIC-CANCER CELLS; SMOOTH-MUSCLE-CELLS; N-TERMINAL PROPIECE; KAPPA-B ACTIVATION; ENDOGENOUS IL-1-ALPHA; STERILE INFLAMMATION; CUTTING EDGE; GENE-EXPRESSION; MYCOBACTERIUM-TUBERCULOSIS

Abstract

Inflammation occurs after disruption of tissue homeostasis by cell stress, injury or infection and ultimately involves the recruitment and retention of cells of hematopoietic origin, which arrive at the affected sites to resolve damage and initiate repair. Interleukin 1α (IL-1α) and IL-1β are equally potent inflammatory cytokines that activate the inflammatory process, and their deregulated signaling causes devastating diseases manifested by severe acute or chronic inflammation. Although much attention has been given to understanding the biogenesis of IL-1β, the biogenesis of IL-1α and its distinctive role in the inflammatory process remain poorly defined. In this review we examine key aspects of IL-1α biology and regulation and discuss its emerging importance in the initiation and maintenance of inflammation that underlie the pathology of many human diseases.