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Author Notes:

Corresponding Author: E-mail: gmvazqu@emory.edu

Conceptualization: GMVP PMS SAR AL FCM JPV.

Data curation: AMB ACM FDM EGM.

Formal analysis: GMVP FDM ACM VUP GGM.

Funding acquisition: GMVP PMS SAR.

Investigation: GGM WBM VUP EGM JVS AMB.

Methodology: GMVP.

Project administration: ACM FDM GGM PMS GMVP.

Resources: JPV.

Supervision: PMS GMVP.

Writing – original draft: GMVP PMS SAR FDM ACM AL FCM.

Writing – review & editing: GMVP PMS SAR AL FCM.

The authors would like to express their sincere gratitude to the staff of UCBE-UADY for their dedication and work and to the residents of the study localities for giving access to their homes for the development of the interventions and collection of field material.

The findings and conclusions in this paper are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.

The authors have declared that no competing interests exist.

Subjects:

Research Funding:

This project received support from Emory Global Health Institute and Marcus Foundation (project #00052002), the Centers for Disease Control and Prevention (CDC: OADS BAA 2016-N-17844) and Mexico’s CONACYT (Project # 000000000255141).

SAR is funded by National Health and Medical Research Council Senior Research Fellowship 1044698.

The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Deltamethrin resistance in Aedes aegypti results in treatment failure in Merida, Mexico

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Journal Title:

PLoS Neglected Tropical Diseases

Volume:

Volume 11, Number 6

Publisher:

, Pages e0005656-e0005656

Type of Work:

Article | Final Publisher PDF

Abstract:

The operational impact of deltamethrin resistance on the efficacy of indoor insecticide applications to control Aedes aegypti was evaluated in Merida, Mexico. A randomized controlled trial quantified the efficacy of indoor residual spraying (IRS) against adult Ae. aegypti in houses treated with either deltamethrin (to which local Ae. aegypti expressed a high degree of resistance) or bendiocarb (to which local Ae. aegypti were fully susceptible) as compared to untreated control houses. All adult Ae. aegypti infestation indices during 3 months post-spraying were significantly lower in houses treated with bendiocarb compared to untreated houses (odds ratio <0.75; incidence rate ratio < 0.65) whereas no statistically significant difference was detected between the untreated and the deltamethrin-treated houses. On average, bendiocarb spraying reduced Ae. aegypti abundance by 60% during a 3-month period. Results demonstrate that vector control efficacy can be significantly compromised when the insecticide resistance status of Ae. aegypti populations is not taken into consideration.

Copyright information:

This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an Open Access work distributed under the terms of the Creative Commons Universal : Public Domain Dedication License (http://creativecommons.org/publicdomain/zero/1.0/).

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