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Author Notes:

Correspondence should be addressed to Dr. Jacques Galipeau, 1111 Highland Avenue, 3009 Wisconsin Institute for Medical Research, Madison, WI 53792., jgalipeau@wisc.edu

Author contributions: A.P., S.N., J.D., S.R., J.L.B., and J.G. designed research; A.P., S.N., Y.W., J.R.M., J.D., S.R., and S.A. performed research; A.P., B.E., and J.G. contributed unpublished reagents/analytic tools; A.P., S.N., Y.W., J.R.M., J.D., S.R., S.A., and J.G. analyzed data; A.P., S.N., S.R., and J.G. wrote the paper.

A.P. and S.N. contributed equally to this work.

The authors declare no competing financial interests.


Research Funding:

This work was supported by National Institutes of Health Grant R01-AI-093881.

National Multiple Sclerosis Society Grant FG1963A1/1 was awarded to J.L.B.


  • Science & Technology
  • Life Sciences & Biomedicine
  • Neurosciences
  • Neurosciences & Neurology
  • B10 CELLS
  • IL-10

Regulatory B Cells Induce Formation of IL-10-Expressing T Cells in Mice with Autoimmune Neuroinflammation


Journal Title:

Journal of Neuroscience Nursing


Volume 36, Number 50


, Pages 12598-12610

Type of Work:

Article | Final Publisher PDF


Although B cells are traditionally known for their role in propagating proinflammatory immune responses, their immunosuppressive effects have only recently begun to be appreciated. How these regulatory B cells (Bregs) suppress the immune response remains to be worked out in detail. In this article, we show that Bregs can induce the formation of conventional FoxP3+regulatory T cells (Tregs), as well as a more recently described CD49b+CD223+ regulatory T-cell subset, known as type 1 regulatory T cells (Tr1s). When Bregs are transferred into mice with experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, they home to the spleen and mesenteric lymph nodes, leading to an expansion of Tregs and Tr1 in vivo. Tregs and Tr1s are also found in greater proportions in the CNS of mice with EAE treated with Bregs and are correlated with the remission of symptoms. The discovery that Bregs induce the formation of regulatory T-cell subsets in vivo may herald their use as immunosuppressive agents in adoptive cellular therapies for autoimmune pathologies.

Copyright information:

© 2016 the authors.

This is an Open Access work distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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