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Author Notes:

Corresponding Author: Chad W.M. Ritenour, M.D., 1365 Clifton Road NE, Building B, Atlanta, GA 30322, 404-778-4697 (O); 404-778-4336 (F), criteno@emory.edu

Conflict of Interest: None

Supplemental Material not available on publisher's website.


Research Funding:

The Childhood Cancer Survivor Study (CCSS) is a collaborative, multi-institutional project, funded as a resource by the National Cancer Institute ( U24 CA55727 ; PI: G.T. Armstrong).


  • Science & Technology
  • Life Sciences & Biomedicine
  • Urology & Nephrology
  • Cancer Survivorship
  • Sexual Dysfunction
  • Erectile Dysfunction
  • Pediatric Cancer
  • SEX

Erectile Dysfunction in Male Survivors of Childhood Cancer-A Report From the Childhood Cancer Survivor Study

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Journal Title:

Journal of Sexual Medicine


Volume 13, Number 6


, Pages 945-954

Type of Work:

Article | Post-print: After Peer Review


Introduction: With survival rates higher than 80%, the number of survivors from pediatric cancer continues to increase. Late effects resulting from cancer and cancer therapy are being characterized, but little information exists on sexual health for men who have survived childhood cancer. Aim: To assess erectile dysfunction (ED) in men who survived childhood and adolescent cancers and to identify potential risk factors for ED. Methods: In total, 1,622 men and 271 eligible brothers in the Childhood Cancer Survivor Study cohort completed the Male Health Questionnaire, which provided information on sexual practices and sexual function. Combined with demographic, cancer, and treatment information from medical record abstraction, results of the Male Health Questionnaire were analyzed using multivariable modeling. The International Index of Erectile Function was used to identify ED in subjects. Main Outcome Measure: International Index of Erectile Function. Results: Survivors (mean age = 37.4 years, SD = 7.3 years) reported significantly lower sexual activity in the year before the survey than the brothers (mean age = 38.8 years, SD = 8.5 years) without cancer. ED was reported by 12.3% (95% CI = 10.4-14.3) of survivors and 4.2% (95% CI = 2.0-7.9) of brothers. Survivors showed significantly higher relative risk (RR) for ED (RR = 2.63, 95% CI = 1.40-4.97). In addition to older age, survivors who were exposed to higher-dose (≥10 Gy) testicular radiation (RR = 3.55, 95% CI = 1.53-8.24), had surgery on the spinal cord or nerves (RR = 2.87, 95% CI = 1.36-6.05), prostate surgery (RR = 6.56, 95% CI = 3.84-11.20), or pelvic surgery (RR = 2.28, 95% CI = 1.04-4.98) were at higher risk for ED. Conclusion: Men who have survived childhood cancer have a greater than 2.6-fold increased risk for ED and certain cancer-specific treatments are associated with increased risk. Attention to sexual health, with its physical and emotional implications, and opportunities for early detection and intervention in these individuals could be important.

Copyright information:

© 2017 Elsevier Inc. All rights reserved. "This is the peer reviewed version of the following article. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

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